Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly

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De Paula, Rafaela C. S. ; Aneni, Ehimen C. ; Costa, Ana Paula R. ; Figueiredo, Valeria N. ; Moura, Filipe A. ; Freitas, Wladimir M. ; Quaglia, Luiz A. ; Santos, Simone N. ; Soares, Alexandre A. ; Nadruz, Wilson, Jr. ; Blaha, Michael ; Blumenthal, Roger ; Agatston, Arthur ; Nasir, Khurram ; Sposito, Andrei C. ; Brazilian Study Healthy Aging Grp

• Tipo de documento: Artigo Científico
• Fonte: BBA CLINICAL; v. 2, p. 6-pg., 2014-12-01.

Resumo

Background: Reduced zinc intake has been related to atherogenesis and arteriosclerosis. Weverified this assumption in very old individuals, which are particularly prone to both zinc deficiency and structural and functional changes in the arterial wall. Methods: Subjects (n= 201, 80-102 years) with uneventful cardiovascular history and who were not in use of anti-inflammatory treatments in the last 30-days were enrolled. Daily intake of zinc, lipid profile, plasma C-reactive protein (CRP), plasma zinc, flow-mediated dilation (FMD), carotid ultrasonography and cardiac computed tomography were obtained. Young's Elastic Modulus, Stiffness Index and Artery Compliance were calculated. Results: There was no significant difference in clinical or laboratorial data between subjects grouped according to plasma zinc tertile, except for CRP (p = 0.01) and blood leukocytes (p = 0.002), of which levels were higher in the upper tertiles. The average daily intake of zinc was not significantly correlated with zinc or CRP plasma levels. The plasma zinc/zinc intake ratiowas inversely correlatedwith plasma CRP levels (-0.18; p= 0.01). There was no significant difference between the plasma zinc tertiles and FMD, carotid intima-media thickness, coronary calcium score, carotid plaque presence, remodeled noncalcified coronary plaques, or low-attenuation noncalcified coronary plaques. Conclusion: Although plasma zinc level is inversely related to systemic inflammatory activity, its plasma levels of daily intake are not associated to alterations in structure or function of the arterial wall. General significance: In the very elderly plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis or atherosclerotic burden at coronary or carotid arteries. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. (AU)

• Processo FAPESP: 12/18044-1 - Efeito do tratamento com niacina sobre o metabolismo do HDL e a função endotelial em pacientes com HDL baixo com ou sem Hipertrigliceridemia.
• Beneficiário: Valéria Nasser Figueiredo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado