Nutritional Strategies to Modulate Intracellular and Extracellular Buffering Capacity During High-Intensity Exercise

Autor(es)

Lancha Junior, Antonio Herbert ; Painelli, Vitor de Salles ; Saunders, Bryan ; Artioli, Guilherme Giannini

• Tipo de documento: Artigo Científico
• Fonte: SPORTS MEDICINE; v. 45, p. 11-pg., 2015-11-01.

Resumo

Intramuscular acidosis is a contributing factor to fatigue during high-intensity exercise. Many nutritional strategies aiming to increase intra-and extracellular buffering capacity have been investigated. Among these, supplementation of beta-alanine (similar to 3-6.4 g/day for 4 weeks or longer), the rate-limiting factor to the intramuscular synthesis of carnosine (i.e. an intracellular buffer), has been shown to result in positive effects on exercise performance in which acidosis is a contributing factor to fatigue. Furthermore, sodium bicarbonate, sodium citrate and sodium/calcium lactate supplementation have been employed in an attempt to increase the extracellular buffering capacity. Although all attempts have increased blood bicarbonate concentrations, evidence indicates that sodium bicarbonate (0.3 g/kg body mass) is the most effective in improving high-intensity exercise performance. The evidence supporting the ergogenic effects of sodium citrate and lactate remain weak. These nutritional strategies are not without side effects, as gastrointestinal distress is often associated with the effective doses of sodium bicarbonate, sodium citrate and calcium lactate. Similarly, paresthesia (i.e. tingling sensation of the skin) is currently the only known side effect associated with beta-alanine supplementation, and it is caused by the acute elevation in plasma beta-alanine concentration after a single dose of beta-alanine. Finally, the co-supplementation of beta-alanine and sodium bicarbonate may result in additive ergogenic gains during high-intensity exercise, although studies are required to investigate this combination in a wide range of sports. (AU)

• Processo FAPESP: 13/04806-0 - Efeitos de 12 semanas de treinamento intermitente de alta intensidade sobre as concentrações intramusculares de carnosina
• Beneficiário: Vitor de Salles Painelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/11221-0 - Elevação artificial da capacidade tamponante muscular: efeitos sobre o desempenho, função e mecanismos relacionados
• Beneficiário: Antonio Herbert Lancha Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Beneficiário: Guilherme Giannini Artioli
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
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• Beneficiário: Guilherme Giannini Artioli
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