| Texto completo | |
| Autor(es): |
Kimura, Lilian
;
Nunes, Kelly
;
Ines Macedo-Souza, Lucia
;
Rocha, Jorge
;
Meyer, Diogo
;
Mingroni-Netto, Regina Celia
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | AMERICAN JOURNAL OF HUMAN BIOLOGY; v. 29, n. 2, p. 11-pg., 2017-03-01. |
| Resumo | |
Objectives: Quilombo remnants are relics of communities founded by runaway or abandoned African slaves, but often with subsequent extensive and complex admixture patterns with European and Native Americans. We combine a genetic study of Y-chromosome markers with anthropological surveys in order to obtain a portrait of quilombo structure and history in the region that has the largest number of quilombo remnants in the state of Sao Paulo. Methods: Samples from 289 individuals from quilombo remnants were genotyped using a set of 17 microsatellites on the Y chromosome ( AmpFlSTR-Yfiler). A subset of 82 samples was also genotyped using SNPs array ( Axiom Human Origins-Affymetrix). We estimated haplotype and haplogroup frequencies, haplotype diversity and sharing, and pairwise genetic distances through F-ST and R-ST indexes. Results: We identified 95 Y chromosome haplotypes, classified into 15 haplogroups. About 63% are European, 32% are African, and 6% Native American. The most common were: R1b ( European, 34.2%), E1b1a ( African, 32.3%), J1 ( European, 6.9%), and Q ( Native American, 6.2%). Genetic differentiation among communities was low ( F-ST = 0.0171; R-ST = 0.0161), and haplotype sharing was extensive. Genetic, genealogical and oral surveys allowed us to detect five main founder haplotypes, which explained a total of 27.7% of the Y chromosome lineages. Conclusions: Our results showed a high European patrilineal genetic contribution among the founders of quilombos, high amounts of gene flow, and a recent common origin of these populations. Common haplotypes and genealogical data indicate the origin of quilombos from a few male individuals. Our study reinforces the importance of a dual approach, involving the analysis of both anthropological and genetic data. (AU) | |
| Processo FAPESP: | 98/14254-2 - Centro de Estudos do Genoma Humano |
| Beneficiário: | Mayana Zatz |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 11/50595-5 - Investigação de novos genes de susceptibilidade à hipertensão essencial em afro-brasileiros |
| Beneficiário: | Lilian Kimura |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 12/18010-0 - Seleção balanceadora no genoma humano: detecção, causas e consequências |
| Beneficiário: | Diogo Meyer |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/08028-1 - CEGH-CEL - Centro de Estudos do Genoma Humano e de Células-Tronco |
| Beneficiário: | Mayana Zatz |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 12/09950-9 - Evolução de genes HLA: diferenciação populacional e sinais de seleção recente em populações nativas e miscigenadas do Brasil |
| Beneficiário: | Kelly Nunes |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |