Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure

Autor(es)

Castro, Erique ; Silva, Tiago E. Oliveira ; Festuccia, William T.

• Tipo de documento: Artigo Científico
• Fonte: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION; v. 31, n. 2, p. 9-pg., 2017-08-01.

Resumo

Beige (or brite, "brown in white") adipocytes are uncoupling protein 1 (UCP1)-positive cells residing in white adipose depots that, depending on the conditions, behave either as classic white adipocytes, storing energy as lipids, or as brown adipocytes, dissipating energy from oxidative metabolism as heat through non-shivering thermogenesis. Because of their thermogenic potential and, therefore, possible usage to treat metabolic diseases such as obesity and type 2 diabetes, beige cells have attracted the attention of many scientists worldwide aiming to develop strategies to safely recruit and activate their thermogenic activity. Indeed, in recent years, a large variety of conditions, molecules (including nutrients) and signaling pathways were reported to promote the recruitment of beige adipocytes. Despite of those advances, the true contribution of beige adipocyte thermogenesis to whole-body energy expenditure is still not completely defined. Herein, we discuss some important aspects that should be considered when studying beige adipocyte biology and the contribution to energy balance and whole-body metabolism. (AU)

• Processo FAPESP: 15/19530-5 - Caracterização do envolvimento do sensor de nutrientes mTOR no desenvolvimento de doenças metabólicas crônicas associadas à obesidade
• Beneficiário: William Tadeu Lara Festuccia
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/23169-9 - Envolvimento de mTORC1 e 2 e de PPARgama no controle do perfil leucocitário, recrutamento e ativação do tecido adiposo marrom e bege induzidos pela exposição ao frio
• Beneficiário: Érique de Castro
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/07062-0 - Caracterização dos mecanismos envolvidos nas ações dos ácidos graxos ômega-3 no balanço energético
• Beneficiário: Tiago Eugênio Oliveira da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado