| Texto completo | |
| Autor(es): |
Markus, Regina P.
;
Fernandes, Pedro A.
;
Kinker, Gabriela S.
;
Cruz-Machado, Sanseray da Silveira
;
Marcola, Marina
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | British Journal of Pharmacology; v. 175, n. 16, p. 12-pg., 2018-08-01. |
| Resumo | |
Melatonin is well known for its circadian production by the pineal gland, and there is a growing body of data showing that it is also produced by many other cells and organs, including immune cells. The chronobiotic role of pineal melatonin, as well as its protective effects in vitro and in vivo, have been extensively explored. However, the interaction between the chronobiotic and defence functions of endogenous melatonin has been little investigated. This review details the current knowledge regarding the coordinated shift in melatonin synthesis from the pineal gland (circadian and monitoring roles) to the regulation of acute immune responses via immune cell production and autocrine effects, producing systemic interactions termed the immune-pineal axis. An acute inflammatory response drives the transcription factor, NFB, to switch melatonin synthesis from pinealocytes to macrophages/microglia and, upon acute inflammatory resolution, back to pinealocytes. The potential pathophysiological relevance of immune-pineal axis dysregulation is highlighted, with both research and clinical implications, across several medical conditions, including host/parasite interaction, neurodegenerative diseases and cancer. (AU) | |
| Processo FAPESP: | 14/27287-0 - Caracterização do sistema melatonérgico de gliomas humanos e sua implicação sobre o grau de agressividade e invasibilidade tumoral |
| Beneficiário: | Gabriela Sarti Kinker |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 15/04557-5 - A ativação do eixo imune-pineal por dieta rica em lipídeos |
| Beneficiário: | Sanseray da Silveira Cruz Machado |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 10/52687-1 - Caracterização do papel da inter-relação adrenal-pineal no contexto do eixo imune-pineal |
| Beneficiário: | Pedro Augusto Carlos Magno Fernandes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/13691-1 - Eixo imune-pineal: integrando a biologia do tempo em condições fisiológicas, fisiopatológicas e patológicas |
| Beneficiário: | Regina Pekelmann Markus |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |