Developmental programming of the female neuroendocrine system by steroids

Autor(es)

Adriana Abruzzese, Giselle ; Crisosto, Nicolas ; Kempinas, Wilma De Grava ; Sotomayor-Zarate, Ramon

• Tipo de documento: Artigo Científico
• Fonte: Journal of Neuroendocrinology; v. 30, n. 10, p. 12-pg., 2018-10-01.

Resumo

Developmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, have a high prevalence in different populations, are multifactorial, and may have a strong environmental component. The environment interacts with organisms, affecting their behaviour, morphology and physiology. This interaction may induce permanent or long-term changes, and organisms may be more susceptible to environmental factors during certain developmental stages, such as the prenatal and early postnatal periods. Several factors have been identified as responsible for inducing the reprogramming of various reproductive and nonreproductive tissues. Among them, both natural and synthetic steroids, such as endocrine disruptors, are known to have either detrimental or positive effects on organisms depending on the dose of exposure, stage of development and biological sexual background. The present review focuses on the action of steroids and endocrine disruptors as agents involved in developmental programming and on their modulation and effects on female neuroendocrine functions. (AU)

• Processo FAPESP: 12/25350-1 - Efeitos da exposição in útero à betametasona sobre aspectos reprodutivos de ratos machos, com ênfase na qualidade espermática e fertilidade: uma abordagem multigeracional
• Beneficiário: Cibele dos Santos Borges
• Modalidade de apoio: Bolsas no Brasil - Doutorado
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• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica