Cannabinoid signalling in embryonic and adult neurogenesis: possible implications for psychiatric and neurological disorders

Autor(es)

de Oliveira, Rubia W. ; Oliveira, Cilene L. ; Guimaraes, Francisco S. ; Campos, Alline C.

• Tipo de documento: Artigo Científico
• Fonte: ACTA NEUROPSYCHIATRICA; v. 31, n. 1, p. 16-pg., 2019-02-01.

Resumo

Cannabinoid signalling modulates several aspects of brain function, including the generation and survival of neurons during embryonic and adult periods. The present review intended to summarise evidence supporting a role for the endocannabinoid system on the control of neurogenesis and neurogenesis-dependent functions. Studies reporting participation of cannabinoids on the regulation of any step of neurogenesis and the effects of cannabinoid compounds on animal models possessing neurogenesis-dependent features were selected from Medline. Qualitative evaluation of the selected studies indicated that activation of cannabinoid receptors may change neurogenesis in embryonic or adult nervous systems alongside rescue of phenotypes in animal models of different psychiatric and neurological disorders. The text offers an overview on the effects of cannabinoids on central nervous system development and the possible links with psychiatric and neurological disorders such as anxiety, depression, schizophrenia, brain ischaemia/stroke and Alzheimer's disease. An understanding of the mechanisms by which cannabinoid signalling influences developmental and adult neurogenesis will help foster the development of new therapeutic strategies for neurodevelopmental, psychiatric and neurological disorders. (AU)

• Processo FAPESP: 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos
• Beneficiário: Francisco Silveira Guimaraes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/05551-0 - Estudo do papel do sistema endocanabinóide nos efeitos comportamentais e plásticos dos fármacos antidepressivos
• Beneficiário: Alline Cristina de Campos
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores