Influence of genetic polymorphisms on oral health-related quality of life after root canal treatment

Autor(es)

Graciane E. R. Queiroz ^[1] ; Thuanny Castilho ^[2] ; Ludmila Silva Guimarães ^[3] ; Vania Gomes Moraes ^[4] ; Erlange Andrade Borges da Silva ^[5] ; Erika Calvano Küchler ^[6] ; Alice Corrêa Silva-Sousa ^[7] ; Manoel Damião Sousa-Neto ^[8] ; Lívia Azeredo Alves Antunes ; Leonardo Santos Antunes

Afiliação do(s) autor(es)

^[1] Fluminense Federal University - Brasil

^[2] Fluminense Federal University - Brasil

^[3] Fluminense Federal University - Brasil

^[4] Fluminense Federal University - Brasil

^[5] Fluminense Federal University - Brasil

^[6] Tuiuti of Paraná University - Brasil

^[7] University of São Paulo - Brasil

^[8] University of São Paulo - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 35, 2024-03-22.

Resumo

Abstract To evaluate the impact of genetic polymorphisms in interleukins (IL1A rs17561, rs1304037; IL10 rs1800871; IL1RN rs9005), nitric oxide (NOS2 rs2779249, rs2897518) and suppressor of cytokine signaling (SOCS1 rs243327, rs33977706) on oral health-related quality of life (OHRQoL) of patients under-going root canal treatment (RCT). Methods: The sample consisted of 108 participants, presenting single-rooted teeth with asymptomatic periapical periodontitis. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) before, seven, and 30 days after RCT. Saliva samples were collected as a source of genomic DNA. Genetic polymorphisms were genotyped by Real-Time PCR using the Taqman method. Univariate and Multivariate analyses were used (p<0.05). Results: A significant difference was observed for the polymorphism rs2297518 in the NOS2 gene in functional limitation in the codominant (p=0.037) and recessive (p=0.001) models; in the physical pain (p<0.001 in both models); in psychological discomfort (p<0.001 in both models); in physical disability (p<0.001 in both models) and in psychological disability (p<0.001 in both models). Polymorphisms in the SOCS1 gene, in the recessive model, rs33977706 (p=0.045) and rs243327 (p=0.019), influenced the OHRQoL in the psychological discomfort domain. Conclusions: Polymorphisms in NOS2 and SOCS1 genes influenced the OHRQoL of patients undergoing RCT. (AU)

• Processo FAPESP: 18/21130-3 - Aspectos moleculares da resposta do hospedeiro na periodontite apical persistente
• Beneficiário: Manoel Damiao de Sousa Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular