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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of genetic polymorphisms on oral health-related quality of life after root canal treatment

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Author(s):
Graciane E. R. Queiroz [1] ; Thuanny Castilho [2] ; Ludmila Silva Guimarães [3] ; Vania Gomes Moraes [4] ; Erlange Andrade Borges da Silva [5] ; Erika Calvano Küchler [6] ; Alice Corrêa Silva-Sousa [7] ; Manoel Damião Sousa-Neto [8] ; Lívia Azeredo Alves Antunes ; Leonardo Santos Antunes
Total Authors: 10
Affiliation:
[1] Fluminense Federal University - Brasil
[2] Fluminense Federal University - Brasil
[3] Fluminense Federal University - Brasil
[4] Fluminense Federal University - Brasil
[5] Fluminense Federal University - Brasil
[6] Tuiuti of Paraná University - Brasil
[7] University of São Paulo - Brasil
[8] University of São Paulo - Brasil
Total Affiliations: 10
Document type: Journal article
Source: Brazilian Dental Journal; v. 35, 2024-03-22.
Abstract

Abstract To evaluate the impact of genetic polymorphisms in interleukins (IL1A rs17561, rs1304037; IL10 rs1800871; IL1RN rs9005), nitric oxide (NOS2 rs2779249, rs2897518) and suppressor of cytokine signaling (SOCS1 rs243327, rs33977706) on oral health-related quality of life (OHRQoL) of patients under-going root canal treatment (RCT). Methods: The sample consisted of 108 participants, presenting single-rooted teeth with asymptomatic periapical periodontitis. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) before, seven, and 30 days after RCT. Saliva samples were collected as a source of genomic DNA. Genetic polymorphisms were genotyped by Real-Time PCR using the Taqman method. Univariate and Multivariate analyses were used (p<0.05). Results: A significant difference was observed for the polymorphism rs2297518 in the NOS2 gene in functional limitation in the codominant (p=0.037) and recessive (p=0.001) models; in the physical pain (p<0.001 in both models); in psychological discomfort (p<0.001 in both models); in physical disability (p<0.001 in both models) and in psychological disability (p<0.001 in both models). Polymorphisms in the SOCS1 gene, in the recessive model, rs33977706 (p=0.045) and rs243327 (p=0.019), influenced the OHRQoL in the psychological discomfort domain. Conclusions: Polymorphisms in NOS2 and SOCS1 genes influenced the OHRQoL of patients undergoing RCT. (AU)

FAPESP's process: 18/21130-3 - Molecular aspects on host response to persistent apical periodontitis
Grantee:Manoel Damiao de Sousa Neto
Support Opportunities: Regular Research Grants