MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training

Autor(es)

Improta-Caria, Alex Cleber ; Rodrigues, Luis Felipe ; Joaquim, Victor Hugo Antonio ; De Sousa, Ricardo Augusto Leoni ; Fernandes, Tiago ; Oliveira, Edilamar Menezes

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 326, n. 3, p. 14-pg., 2024-03-08.

Resumo

Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity develop long-term fibrotic processes in the heart, promoting pathological cardiac remodeling, including after myocardial infarction, reparative fibrotic processes also occur. These processes are regulated by many intracellular signaling pathways that have not yet been completely elucidated, including those associated with microRNA (miRNA) expression. miRNAs are small RNA transcripts (18-25 nucleotides in length) that act as posttranscriptionally regulators of gene expression, inhibiting or degrading one or more target messenger RNAs (mRNAs), and proven to be involved in many biological processes such as cell cycle, differentiation, proliferation, migration, and apoptosis, directly affecting the pathophysiology of several diseases, including cardiac fibrosis. Exercise training can modulate the expression of miRNAs and it is known to be beneficial in various cardiovascular diseases, attenuating cardiac fibrosis processes. However, the signaling pathways modulated by the exercise associated with miRNAs in cardiac fibrosis were not fully understood. Thus, this review aims to analyze the expression of miRNAs that modulate signaling pathways in cardiac fibrosis processes that can be regulated by exercise training. (AU)

• Processo FAPESP: 21/06229-6 - Efeito da associação entre hipertensão arterial e câncer de Walker-256 sobre o fenótipo cardíaco e a progressão tumoral: potencial terapêutico do treinamento físico aeróbio
• Beneficiário: Luis Felipe Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 22/03138-2 - Funções e mecanismos reguladores do lincRNA-p21 no músculo esquelético: papel sobre as células satélites, miogênese, trofismo, contratilidade, desempenho físico e reparo de lesões
• Beneficiário: Tiago Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Projeto Inicial
• Processo FAPESP: 15/22814-5 - Câncer e coração: novos paradigmas de diagnóstico e tratamento
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/22579-4 - MicroRNAs exossômicos como biomarcadores circulantes e mediadores do efeito cardioprotetor em pacientes submetidos a terapias contra o câncer
• Beneficiário: Edilamar Menezes de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular