Omega-3 Fatty Acids and Hypertriglyceridemia in HIV-Infected Subjects on Antiretroviral Therapy: Systematic Review and Meta-analysis

Autor(es)

Oliveira, Julicristie M. ^[1] ; Rondo, Patricia H. C.

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sch Publ Hlth, FSP USP, BR-01246904 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: HIV CLINICAL TRIALS; v. 12, n. 5, p. 268-274, SEP-OCT 2011.
• Citações Web of Science: 13

Resumo

Purpose: Antiretroviral therapy (ART) changed the course of AIDS. However, it has been associated with chronic metabolic complications including hypertriglyceridemia. The aim of this systematic review is to evaluate the effects of marine omega-3 fatty acids in triglycerides concentrations of HIV-infected subjects on ART. Methods: Thirty-three articles were found in a PubMed search; 6 met the inclusion criteria, and 4 of them were considered of adequate quality and included. Meta-analysis with fixed effects was performed and weighted mean differences (WMD; 95% CI) were described. Results: The overall reduction of triglycerides concentrations after 8 to 16 weeks of treatment with 900 to 3360 mg omega-3/day was WMD -80.34 mg/dL (95% CI, -129.08 to -31.60). Short-term (4 to 8 weeks) and a long-term (12 to 16 weeks) interventions were associated with a WMD -134.36 mg/dL (95% CI, -208.04 to -60.69) and WMD -54.09 mg/dL (95% CI, -115.77 to 7.59), respectively. The pooled result of studies with mean triglycerides >= 300 mg/dL at baseline and 1800 to 2900 mg omega-3/day was WMD -129.72 mg/dL (95% CI, -206.54 to -52.91). Conclusion: Different doses of omega-3 fatty acids significantly reduce triglycerides concentrations, confirming the potential applicability of this nutrient on the management of hypertriglyceridemia in HIV-infected subjects on ART. (AU)

• Processo FAPESP: 08/50970-8 - Efeito da suplementação com ômega-3 nos parâmetros inflamatórios, bioquímicos e cardiovasculares de adultos com HIV em HAART: ensaio clínico controlado, aleatorizado e duplo-cego
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/55532-9 - Efeito da suplementação com ômega-3 nos parâmetros inflamatórios, bioquímicos e cardiovasculares de adultos com HIV em HAART: ensaio clínico, aleatorizado, controlado e duplo-cego
• Beneficiário: Julicristie Machado de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado