"Characterization and stability of α-tocopherol loaded solid lipid nanoparticles formulated with different fully hydrogenated vegetable oils"

Autor(es)

Stahl, Marcella Aparecida ; Luedtke, Fernanda Luisa ; Grimaldi, Renato ; Gigante, Mirna Lucia ; Ribeiro, Ana Paula Badan

• Tipo de documento: Artigo Científico
• Fonte: Food Chemistry; v. 439, p. 9-pg., 2023-12-08.

Resumo

Solid lipid nanoparticles can be compatible with several bioactive compounds and confer a differentiated crystalline structure. This study aimed to produce alpha-tocopherol loaded solid lipid nanoparticles with fully hydrogenated oils and fats from palm oil, soybean oil, and crambe oil, by high-pressure homogenization, using lecithin as an emulsifier. After recrystallization of solid lipid nanoparticles, dispersions were evaluated until 60 days of storage for particle size, polydispersity index, zeta potential, microstructure, dispersion stability and alpha-tocopherol quantification. alpha-tocopherol loaded solid lipid nanoparticles showed particle sizes and zeta potential values considered adequate for this type of particle. Presence of alpha-tocopherol altered thermal behavior of the particles, leading to increased crystallinity, with no changes in polymorphism, when compared to the unloaded solid lipid nanoparticles. All alpha-tocopherol loaded solid lipid nanoparticles dispersions showed stability with no losses of alpha-tocopherol, indicating their potential as a carrier for this compound in fortified foods. (AU)

• Processo FAPESP: 16/11261-8 - Óleos, gorduras e nanotecnologia: desenvolvimento de nanopartículas lipidicas sólidas e carreadores lipídicos nanoestruturados para incorporação de compostos bioativos lipofílicos
• Beneficiário: Ana Paula Badan Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/27354-3 - Arquitetura de sistemas de liberação coloidais: qual é o papel da estrutura na digestibilidade?
• Beneficiário: Rosiane Lopes da Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/03172-0 - Desenvolvimento de carreadores lipídicos nanoestruturados para incorporação de compostos bioativos lipofílicos
• Beneficiário: Fernanda Luisa Lüdtke
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/05176-6 - Avaliação da digestibilidade in vitro de carreadores lipídicos nanoestruturados com incorporação de ²-caroteno
• Beneficiário: Fernanda Luisa Lüdtke
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado