Unveiling microtubule dynamics in lung cancer: Recent findings and prospects for drug delivery and treatment

Autor(es):Mostrar menos -

Yukuyama, Megumi Nishitani ; de Souza, Aline ; Bazan Henostroza, Mirla Anali ; Barros de Araujo, Gabriel Lima ; Lobenberg, Raimar ; Faria, Rafael de Oliveira ; de Souza, Gabriel Batista ; Ferreira Guimaraes, Lara Mendes ; Lameu, Claudiana ; Folchini, Beatriz Rabelo ; Peroni, Camilla Midori ; Oliveira, Isabela Fernandes ; Saito Miyagi, Mariana Yasue ; Bou-Chacra, Adia Araci

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 89, p. 14-pg., 2023-10-12.

Resumo

Microtubules are dynamic proteins that play crucial roles in the normal functions of cells. Chromosome missegregation driven by microtubules during cell division can lead to several diseases, including cancer. Among them, lung cancer is one of the leading causes of tumor mortality worldwide, and presents several limitations including early prognosis and currently available treatments. This review revisited the role of several features of microtubules in lung cancer, which include microtubule isotypes, bioelectrical function of microtubules, kinetochoreand mitochondrial-microtubule interactions, as well as ciliogenesis in tumor development and progression. These findings support recent discoveries of biomarkers and nanotechnology-based microtubule targeting drugs for development of early prognosis or alternative treatments. Thus, this manuscript aims to deliver new insights and deepen understanding of these intriguing interactions of microtubules and lung cancer, which will serve as a basis for the future development of new alternatives of delivery systems to overcome the limitations of current treatments. (AU)

• Processo FAPESP: 16/26189-0 - EMU concedido no processo 2015/19128-4: tissue FAXS Plus
• Beneficiário: Claudiana Lameu
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 22/02193-0 - Estudo do reposicionamento de fármacos antiparasitários para o tratamento de Neoplasias empregando sistemas nanoestruturados
• Beneficiário: Nádia Araci Bou-Chacra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/22713-2 - Estudo do reposicionamento do flubendazol para o tratamento de câncer de pulmão e meningoencefalite empregando nanossistema lipídico oral
• Beneficiário: Megumi Nishitani Yukuyama
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/04998-2 - Formulações nanocristalinas e dispersões sólidas amorfas para a melhoria de terapias antitumorais
• Beneficiário: Gabriel Lima Barros de Araujo
• Modalidade de apoio: Auxílio à Pesquisa - Regular