| Texto completo | |
| Autor(es): |
Borsoi, Felipe Tecchio
;
da Silva, Gilnei Bruno
;
Manica, Daiane
;
Bagatini, Margarete Dulce
;
Pastore, Glaucia Maria
;
Arruda, Henrique Silvano
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRIENTS; v. 16, n. 17, p. 20-pg., 2024-09-01. |
| Resumo | |
Cutaneous melanoma is an aggressive type of skin cancer that is recognized for its high metastatic potential and the challenges it presents in its treatment. There has been increasing interest in plant extracts and their potential applications in melanoma. The present study aimed to investigate the content of individual phenolic compounds in ara & ccedil;& aacute;-boi extract, evaluate their antioxidant activity, and explore their effects on cell viability, migration properties, oxidative stress levels, and protein expression in the human metastatic melanoma cell line SK-MEL-28. HPLC-DAD analysis identified 11 phenolic compounds in the ara & ccedil;& aacute;-boi extract. Trans-cinnamic acid was the main phenolic compound identified; therefore, it was used alone to verify its contribution to antitumor activities. SK-MEL-28 melanoma cells were treated for 24 h with different concentrations of ara & ccedil;& aacute;-boi extract and trans-cinnamic acid (200, 400, 600, 800, and 1600 mu g/mL). Both the ara & ccedil;& aacute;-boi extract and trans-cinnamic acid reduced cell viability, cell migration, and oxidative stress in melanoma cells. Additionally, they modulate proteins involved in apoptosis and inflammation. These findings suggest the therapeutic potential of ara & ccedil;& aacute;-boi extract and its phenolic compounds in the context of melanoma, especially in strategies focused on preventing metastasis. Additional studies, such as the analysis of specific signaling pathways, would be valuable in confirming and expanding these observations. (AU) | |
| Processo FAPESP: | 20/08761-4 - Caracterização química de compostos bioativos de plantas alimentícias não convencionais (panc) para o desenvolvimento de produtos com apelo funcional |
| Beneficiário: | Glaucia Maria Pastore |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |