| Texto completo | |
| Autor(es): |
Smith, Bradley J.
;
Silva-Costa, Licia C.
;
Martins-de-Souza, Daniel
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOPHYSICAL REVIEWS; v. 13, n. 6, p. 12-pg., 2021-12-01. |
| Resumo | |
As more uses for biomarkers are sought after for an increasing number of disease targets, single-target biomarkers are slowly giving way for biomarker panels. These panels incorporate various sources of biomolecular and clinical data to guarantee a higher robustness and power of separation for a clinical test. Multifactorial diseases such as psychiatric disorders show great potential for clinical use, assisting medical professionals during the analysis of risk and predisposition, disease diagnosis and prognosis, and treatment applicability and efficacy. More specific tests are also being developed to assist in ruling out, distinguishing between, and confirming suspicions of multifactorial diseases, as well as to predict which therapy option may be the best option for a given patient's biochemical profile. As more complex datasets are entering the field, involving multi-omic approaches, systems biology has stepped in to facilitate the discovery and validation steps during biomarker panel generation. Filtering biomolecules and clinical data, pre-validating and cross-validating potential biomarkers, generating final biomarker panels, and testing the robustness and applicability of those panels are all beginning to rely on machine learning and systems biology and research in this area will only benefit from advances in these approaches. (AU) | |
| Processo FAPESP: | 18/03422-7 - Identificação de biomarcadores em depressão geriátrica através de análise proteômica |
| Beneficiário: | Licia Carla da Silva Costa |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/25957-2 - Caracterização da função das vesículas sinápticas e liberação de neurotransmissores durante o neurodesenvolvimento na Esquizofrenia |
| Beneficiário: | Daniel Martins-de-Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/25588-1 - Da compreensão básica a biomarcadores clínicos para a esquizofrenia: um estudo multidisciplinar centrado na neuroproteômica |
| Beneficiário: | Daniel Martins-de-Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 16/07948-8 - Papel da fosfodiesterase CNP associada a mielina com a esquizofrenia |
| Beneficiário: | Bradley Joseph Smith |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 20/04746-0 - Compreensão das bases moleculares e do papel dos fatores de risco na infecção por SARS-CoV-2 em modelos pré-clínicos |
| Beneficiário: | Daniel Martins-de-Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |