Development of essential oils inclusion complexes: a nanotechnology approach with enhanced thermal and light stability

Autor(es)

Procopio, Fernanda Ramalho ; Brexo, Ramon Peres ; Vitolano, Luis Eduardo Sousa ; Martins, Maria Eduarda da Mata ; Astolfo, Maria Eduarda de Almeida ; Bogusz Junior, Stanislau ; Ferreira, Marcos David

• Tipo de documento: Artigo Científico
• Fonte: DISCOVER NANO; v. 19, n. 1, p. 15-pg., 2024-12-08.

Resumo

Essential oils (EOs) are volatile compounds that may have antimicrobial and antioxidant properties. Despite their potential application, low water solubility and chemical instability are limiting factors. Nanoencapsulation processes can overcome this problem, protecting against external factors and promoting a moderate release. Therefore, the objective of the present study was to encapsulate Cymbopogon citratus (CC) and Origanum vulgare (OV) essential oils in beta-cyclodextrin (beta CD) complexes. Different ratios (w/w) between beta CD and EOs (96:4, 92:8, 90:10, 88:12) were tested, seeking greater entrapment efficiency. The particles were characterized by yield, entrapment efficiency, size distribution, morphology, crystallinity, infrared spectroscopy, and thermal behavior. Furthermore, the thermal (70 degrees C) and photochemical (UV) stability of the free and encapsulated EO was evaluated for 48 h. The results showed that the beta CD-CC 90:10 and beta CD-OV 90:10 formulations presented greater entrapment efficiency. Crystalline structures of varying sizes (200 to 800 nm), trapezoidal shape, and tendency to aggregation were obtained. Changes in the beta CD crystalline organization and the suppression of characteristic free oil absorption bands suggest the EO entrapment. Regarding stability results, beta CD-CC remained constant when CC showed losses of 20% (photodegradation) and 60% (thermal degradation) after 48 h of stress exposure. Free OV showed slight variations in absorbance over time, while beta CD-OV remained constant over 24 h (thermal degradation) and maintained 60% of oil over 48 h of photo exposure. Furthermore, OV and CC demonstrate color change over time, while beta CD-OV and beta CD-CC remained constant. The results demonstrate that nanoencapsulation can be an interesting tool for protecting EOs. (AU)

• Processo FAPESP: 23/17653-9 - Desenvolvimento de antifúngicos naturais nanoencapsulados para aplicação na conservação de frutas pós-colheita
• Beneficiário: Fernanda Ramalho Procopio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 22/03229-8 - Síntese, caracterização e aplicações de solventes eutéticos naturais profundos (NADES)
• Beneficiário: Stanislau Bogusz Junior
• Modalidade de apoio: Auxílio à Pesquisa - Projeto Inicial
• Processo FAPESP: 23/14371-2 - Revestimentos nanocompósitos funcionalizados com óleos essenciais (OEs) encapsulados e não encapsulados.
• Beneficiário: Ramon Peres Brexó
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 22/10686-6 - Aplicação da nanotecnologia para o desenvolvimento de novos revestimentos antimicrobianos baseados em compostos de origem vegetal (plant-based) para conservação pós-colheita de frutas e hortaliças
• Beneficiário: Marcos David Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular