Chemical Characterization and Evaluation of the Anti-Cancer Potential of Flowers from Fridericia platyphylla (Bignoniaceae)

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Marcelino S. do Rosário ; Helena Mannochio-Russo ^[2] ; Ana L. P. dos Santos ^[3] ; Aglaete A. Pinheiro ^[4] ; Luna N. Vasconcelos ^[5] ; Ana Paula S. A. Santos ^[6] ; Lila T. de Oliveira ^[7] ; Monique M. Martins ^[8] ; Marcelo S. de Andrade ^[9] ; Maria D. S. B. Nascimento ^[10] ; Vanderlan S. Bolzani ^[11] ; Josélia A. Lima ^[12] ; Cláudia Q. da Rocha ^[13]

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 36, n. 2 2024-08-23.

Resumo

In this study, we aimed to investigate the anticancer activity of the extract, fractions, and isolated compounds of the flowers of Fridericia platyphylla, and to characterize the bioactive compounds. The chemical diversity of the extracts and fractions was investigated using liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). We were able to annotate 26 compounds from the classes of flavones, flavonols, flavanones, isoflavones, and cinnamic acid and its derivatives. The dichloromethane fraction showed greater cytotoxicity at a concentration of 100 µg mL−1. In addition, the inhibitory concentrations of the dichloromethane fraction were 22.14 and 30.9 µg mL−1 for MCF-7 and MDA-MB-231 cell lines, respectively, and were capable of inhibiting tumor cell migration. Brachydins A and C were isolated from the dichloromethane fraction and showed the greatest cytotoxicity. The results obtained from this study show the potential biological effect of F. platyphylla flowers as a possible antitumor pharmacological agent. (AU)

• Processo FAPESP: 17/19702-6 - Abordagens ômicas integradas para a avaliação da dinâmica micromolecular fenotípica de cultivares de Glycine max (soja) geneticamente modificados com vistas a tolerância à estresses hídricos
• Beneficiário: Paula Carolina Pires Bueno
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/16970-7 - Estudo do impacto da função de eIF5A no perfil proteômico celular utilizando o modelo de Saccharomyces cerevisiae
• Beneficiário: Cleslei Fernando Zanelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático