Chemical Characterization and Evaluation of the Anti-Cancer Potential of Flowers from Fridericia platyphylla (Bignoniaceae)

Author(s):Show less -

Marcelino S. do Rosário ; Helena Mannochio-Russo ^[2] ; Ana L. P. dos Santos ^[3] ; Aglaete A. Pinheiro ^[4] ; Luna N. Vasconcelos ^[5] ; Ana Paula S. A. Santos ^[6] ; Lila T. de Oliveira ^[7] ; Monique M. Martins ^[8] ; Marcelo S. de Andrade ^[9] ; Maria D. S. B. Nascimento ^[10] ; Vanderlan S. Bolzani ^[11] ; Josélia A. Lima ^[12] ; Cláudia Q. da Rocha ^[13]

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 36, n. 2 2024-08-23.

Abstract

In this study, we aimed to investigate the anticancer activity of the extract, fractions, and isolated compounds of the flowers of Fridericia platyphylla, and to characterize the bioactive compounds. The chemical diversity of the extracts and fractions was investigated using liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). We were able to annotate 26 compounds from the classes of flavones, flavonols, flavanones, isoflavones, and cinnamic acid and its derivatives. The dichloromethane fraction showed greater cytotoxicity at a concentration of 100 µg mL−1. In addition, the inhibitory concentrations of the dichloromethane fraction were 22.14 and 30.9 µg mL−1 for MCF-7 and MDA-MB-231 cell lines, respectively, and were capable of inhibiting tumor cell migration. Brachydins A and C were isolated from the dichloromethane fraction and showed the greatest cytotoxicity. The results obtained from this study show the potential biological effect of F. platyphylla flowers as a possible antitumor pharmacological agent. (AU)

• FAPESP's process: 17/19702-6 - Integrated omics approaches for the evaluation of the micromolecular phenotypic dynamics of Glycine max (soja) genetically modified for water stress tolerance
• Grantee: Paula Carolina Pires Bueno
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 16/16970-7 - Study of the impact of the role of eIF5A in the cell proteomic profile using Saccharomyces cerevisiae as a model
• Grantee: Cleslei Fernando Zanelli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants