| Texto completo | |
| Autor(es): |
Ureshino, Rodrigo Portes
;
Erustes, Adolfo Garcia
;
Bassani, Taysa Bervian
;
Wachilewski, Patricia
;
Guarache, Gabriel Cicolin
;
Nascimento, Ana Carolina
;
Costa, Angelica Jardim
;
Smaili, Soraya Soubhi
;
da Silva Pereira, Gustavo Jose
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 23, p. 28-pg., 2019-12-01. |
| Resumo | |
Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in many physiological processes. For example, the spatial and temporal organization of Ca2+ signaling in the central nervous system is fundamental for neurotransmission, where local changes in cytosolic Ca2+ concentration are needed to transmit information from neuron to neuron, between neurons and glia, and even regulating local blood flow according to the required activity. However, under pathological conditions, Ca2+ homeostasis is altered, with increased cytoplasmic Ca2+ concentrations leading to the activation of proteases, lipases, and nucleases. This review aimed to highlight the role of Ca2+ signaling in neurodegenerative disease-related apoptosis, where the regulation of intracellular Ca2+ homeostasis depends on coordinated interactions between the endoplasmic reticulum, mitochondria, and lysosomes, as well as specific transport mechanisms. In neurodegenerative diseases, alterations-increased oxidative stress, energy metabolism alterations, and protein aggregation have been identified. The aggregation of alpha-synuclein, beta-amyloid peptide (A beta), and huntingtin all adversely affect Ca2+ homeostasis. Due to the mounting evidence for the relevance of Ca2+ signaling in neuroprotection, we would focus on the expression and function of Ca2+ signaling-related proteins, in terms of the effects on autophagy regulation and the onset and progression of neurodegenerative diseases. (AU) | |
| Processo FAPESP: | 17/10863-7 - Estudo da lipofagia mediada pelos receptores two-pore channels |
| Beneficiário: | Gustavo José da Silva Pereira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/20073-2 - Estudo da autofagia no processo de proteção celular de ratas senescentes |
| Beneficiário: | Soraya Soubhi Smaili |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/20796-2 - Estudo da autofagia mediada pelos receptores de estrógeno para combater a toxicidade da proteína tau em modelos celular e animal de zebrafish |
| Beneficiário: | Rodrigo Portes Ureshino |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 17/23616-8 - Análise da autofagia mediada pelos receptores de progestágenos para combater a toxicidade da proteína tau em modelo celular de tauopatia |
| Beneficiário: | Taysa Bervian Bassani |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |