The effects of lipoic acid and alpha-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial

Autor(es)

de Oliveira, Andreia Madruga ^[1] ; Carvalho Rondo, Patricia Helen ^[1] ; Luzia, Liania Alves ^[1] ; D'Abronzo, Francisco Homero ^[2] ; Illison, Vanessa Kristine ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

^[2] Jundiai Med Sch, Dept Internal Med, BR-13202550 Jundiai, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Diabetes Research and Clinical Practice; v. 92, n. 2, p. 253-260, MAY 2011.
• Citações Web of Science: 38

Resumo

Antioxidants probably play an important role in the etiology of type 2 diabetes (DM2). This study evaluated the effects of supplementation with lipoic acid (LA) and alpha-tocopherol on the lipid profile and insulin sensitivity of DM2 patients. A randomized, double-blind, placebo-controlled trial involving 102 DM2 patients divided into four groups to receive daily supplementation for 4 months with: 600 mg LA (n = 26); 800 mg alpha-tocopherol (n = 25); 800 mg alpha-tocopherol + 600 mg LA (n = 25); placebo (n = 26). Plasma alpha-tocopherol, lipid profile, glucose, insulin, and the HOMA index were determined before and after supplementation. Differences within and between groups were compared by ANOVA using Bonferroni correction. Student's t-test was used to compare means of two independent variables. The vitamin E/total cholesterol ratio improved significantly in patients supplemented with vitamin E + LA and vitamin E alone (p <= 0.001). There were improvements of the lipid fractions in the groups receiving LA and vitamin E alone or in combination, and on the HOMA index in the LA group, but not significant. The results suggest that LA and vitamin E supplementation alone or in combination did not affect the lipid profile or insulin sensitivity of DM2 patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 04/04108-1 - O impacto da suplementacao com acido alfa-lipoico e alfa-tocoferol no controle da resistencia a insulina e outros componentes da sindrome metabolica em pacientes com diabetes mellitus tipo 2.
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Regular