| Texto completo | |
| Autor(es): |
de Oliveira Cavalheiro, Rollssman
;
Brognara, Fernanda
;
da Silva, Carlos Alberto Aguiar
;
Castania, Jaci Airton
;
Molina, Carlos Augusto Fernandes
;
Murphy, David
;
Romano, Minna Moreira Dias
;
Salgado, Helio Cesar
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACTA PHYSIOLOGICA; v. 241, n. 8, p. 16-pg., 2025-08-01. |
| Resumo | |
AimTo evaluate the effect of carotid sinus nerve stimulation (CSNS) in the progression of cardiorenal syndrome type 1 (CRS1), 3 days after acute myocardial infarction (AMI).MethodsMale rats were divided into four groups. CSNS was applied daily for 10 min over 3 days. Cardiac, renal, and inflammatory parameters characterized the CRS1 and the electroceutical effects of CSNS.ResultsCSNS reduced the ischemic zone compared to the AMI group not exposed to CSNS (32.7% +/- 2.2% vs. 8.0% +/- 1.8%). Heart rate (bpm) was increased in the AMI group, showing 440 +/- 7.6 at 48 h and 428 +/- 1.0 at 60 h post-AMI. Additionally, arterial pressure (mmHg) was increased in the AMI group at 48 h, as follows: mean: 98 +/- 1.7, diastolic: 89 +/- 2.1, and systolic: 122 +/- 5.3. In contrast, the CSNS + AMI group showed significant reductions of these parameters: mean: 79 +/- 2.0, diastolic, 66 +/- 1.7, and systolic: 99 +/- 2.7. Renal injury was confirmed by increased apoptosis in the AMI group. A significant increase in TNF-alpha was observed in both heart and kidneys (pg/mg of tissue) in the AMI group and reduced IL-6 and IL-1 beta levels in the CSNS + AMI group, indicating an attenuation of the inflammatory responses by CSNS.ConclusionsThis study demonstrates early cardiac and renal dysfunction in CRS1 following AMI, associated with elevated inflammatory markers (TNF-alpha, IL-6, and IL-1 beta) and renal apoptosis. Therefore, CSNS appears to be a promising electroceutical approach for CRS1. Besides, on the basis of previous studies from our laboratory, CSNS involves stimulation of the baroreflex, activating the parasympathetic and inhibiting the sympathetic nervous system. (AU) | |
| Processo FAPESP: | 20/06043-7 - Modulação autonômica (simpática e parassimpática) das respostas inflamatórias e cardiocirculatórias em situações fisiopatológicas clínicas e experimentais |
| Beneficiário: | Helio Cesar Salgado |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 21/03764-8 - Identificação de receptores de citocinas e do receptor Toll-like 4 nas aferências barorreceptoras de ratos submetidos à inflamação sistêmica |
| Beneficiário: | Fernanda Brognara Penteado Dias |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |