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| Autor(es): Mostrar menos - |
Valim, Joao Marcos Bovetto de Campos
;
Herreira, Vinicius Laerte Silva
;
Gongora, Ana Laura dos Santos Munhoz
;
Beltrao, Lauro Cesar Ferreira
;
dos Santos, Eduardo Solano Pina
;
de Oliveira, Brenda Santos
;
Pugliesi, Guilherme
;
Santana, Miguel Henrique de Almeida
;
Polizel, Guilherme Henrique Gebim
;
Colnago, Luiz Alberto
;
Ocampos, Fernanda Maria Marins
;
Ramirez-Zamudio, German Dario
;
Silva, Saulo Luz
;
Consolo, Nara Regina Brandao
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | METABOLITES; v. 15, n. 12, p. 16-pg., 2025-11-25. |
| Resumo | |
Background: Beef tenderness is a key quality attribute that significantly influences consumer satisfaction; however, it exhibits considerable variability due to both genetic and environmental factors. While genomic selection based on Expected Progeny Differences (EPDs) has improved the accuracy of predictions, a substantial portion of tenderness variability remains unexplained. Metabolomics has emerged as a valuable approach to address this gap, as metabolites reflect gene-environment interactions and may serve as biomarkers for complex traits such as meat tenderness. Objectives: This study aimed to integrate genomic and metabolomic data to identify genetic loci associated with serum metabolites in Nellore calves, offspring of sires with contrasting EPDs for meat tenderness. Methods: Ninety-five male calves were evaluated and divided into two groups according to the sires' genetic merit: FA-T (favorable EPD for tenderness, n = 45) and UN-T (unfavorable EPD for tenderness, n = 46). Blood serum samples were analyzed by 1H NMR spectroscopy to quantify 40 metabolites, and genotyping was performed using a medium-density SNP panel. Metabolite quantitative trait loci (mQTL) were identified using the MatrixEQTL package, and metabolic enrichment analysis was performed in MetaboAnalyst 6.0. Results: In the FA-T group, SNPs were associated with metabolites such as phenylalanine, tyrosine, and succinate, suggesting enhanced oxidative metabolism and preservation of proteolysis. In the UN-T group, associations of pyruvate, creatinine, and glutamine with distinct SNPs indicated greater reliance on anaerobic glycolysis and early ATP consumption, potentially impairing phosphorylation and postmortem proteolytic activity. Conclusions: These findings suggest that genetic selection for tenderness may induce early divergent metabolic profiles, likely leading to persistent differences in postmortem biochemical pathways, with important implications for meat tenderness. (AU) | |
| Processo FAPESP: | 25/00509-8 - Desenvolvimento e aplicações das espectroscopias de rmn e infravermelho na análise de insumos e produtos agrícolas |
| Beneficiário: | Luiz Alberto Colnago |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/16074-2 - Caracterização do metabótipo de bezerros Nelore ao nascimento e desmame progênie de touros com variação genética para maciez da carne |
| Beneficiário: | Vinicius Laerte Silva Herreira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 20/08845-3 - Abordagem metabolômica para melhora da maciez da carne de bovinos Nelore: o conceito de metabotype e biomarcadores |
| Beneficiário: | Nara Regina Brandão Cônsolo |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 23/00661-9 - Abordagem integrômica de dados ômicos de machos Nelore progênie de touros com variação genética para maciez da carne. |
| Beneficiário: | João Marcos Bovetto de Campos Valim |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 23/11605-2 - Otimização de métodos de aquisição espectral de ressonância magnética nuclear para análise metabolômica de soro bovino: validação de processos |
| Beneficiário: | Fernanda Maria Marins Ocampos |
| Modalidade de apoio: | Bolsas no Brasil - Programa Fixação de Jovens Doutores |