In situ apoptosis of adaptive immune cells and the cellular escape of rabies virus in CNS from patients with human rabies transmitted by Desmodus rotundus

Autor(es)

Fernandes, Elaine Raniero ^[1] ; de Andrade, Jr., Heitor Franco ^{[1, 2]} ; Penteado Lancellotti, Carmen Lucia ^[3] ; Simoes Quaresma, Juarez Antonio ^[4] ; Demachki, Samia ^[4] ; da Costa Vasconcelos, Pedro Fernando ^[5] ; Seixas Duarte, Maria Irma ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Lab Disciplina Patol Molestias Transmissiveis, Dept Patol, Sao Paulo - Brazil

^[2] Inst Med Trop Sao Paulo, Lab Protozool, Sao Paulo - Brazil

^[3] Fac Ciencias Med Santa Casa Sao Paulo, Dept Patol, Sao Paulo - Brazil

^[4] Fed Univ Para, Nucleo Med Trop, BR-66059 Belem, Para - Brazil

^[5] Inst Evandro Chagas, Belem, Para - Brazil

• Tipo de documento: Artigo Científico
• Fonte: VIRUS RESEARCH; v. 156, n. 1-2, p. 121-126, MAR 2011.
• Citações Web of Science: 10

Resumo

The aim of the current study was to investigate the apoptosis of neurons, astrocytes and immune cells from human patients that were infected with rabies virus by vampire bats bite. Apoptotic neurons were identified by their morphology and immune cells were identified using double immunostaining. There were very few apoptotic neurons present in infected tissue samples, but there was an increase of apoptotic infiltrating CD4+ and TCD8+ adaptive immune cells in the rabies infected tissue. No apoptosis was present in NK, macrophage and astrocytes. The dissemination of the human rabies virus within an infected host may be mediated by viral escape of the virus from an infected cell and may involve an anti-apoptotic mechanism, which does not kill the neuron or pro-apoptosis of TCD4+ and TCD8+ lymphocytes and which allows for increased proliferation of the virus within the CNS by attenuation of the adaptive immune response. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 08/03786-7 - Morte neuronal e resposta inflamatória in situ em sistema nervoso central de pacientes com raiva transmitida por morcegos
• Beneficiário: Maria Irma Seixas Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular