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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In situ apoptosis of adaptive immune cells and the cellular escape of rabies virus in CNS from patients with human rabies transmitted by Desmodus rotundus

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Author(s):
Fernandes, Elaine Raniero [1] ; de Andrade, Jr., Heitor Franco [1, 2] ; Penteado Lancellotti, Carmen Lucia [3] ; Simoes Quaresma, Juarez Antonio [4] ; Demachki, Samia [4] ; da Costa Vasconcelos, Pedro Fernando [5] ; Seixas Duarte, Maria Irma [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Lab Disciplina Patol Molestias Transmissiveis, Dept Patol, Sao Paulo - Brazil
[2] Inst Med Trop Sao Paulo, Lab Protozool, Sao Paulo - Brazil
[3] Fac Ciencias Med Santa Casa Sao Paulo, Dept Patol, Sao Paulo - Brazil
[4] Fed Univ Para, Nucleo Med Trop, BR-66059 Belem, Para - Brazil
[5] Inst Evandro Chagas, Belem, Para - Brazil
Total Affiliations: 5
Document type: Journal article
Source: VIRUS RESEARCH; v. 156, n. 1-2, p. 121-126, MAR 2011.
Web of Science Citations: 10
Abstract

The aim of the current study was to investigate the apoptosis of neurons, astrocytes and immune cells from human patients that were infected with rabies virus by vampire bats bite. Apoptotic neurons were identified by their morphology and immune cells were identified using double immunostaining. There were very few apoptotic neurons present in infected tissue samples, but there was an increase of apoptotic infiltrating CD4+ and TCD8+ adaptive immune cells in the rabies infected tissue. No apoptosis was present in NK, macrophage and astrocytes. The dissemination of the human rabies virus within an infected host may be mediated by viral escape of the virus from an infected cell and may involve an anti-apoptotic mechanism, which does not kill the neuron or pro-apoptosis of TCD4+ and TCD8+ lymphocytes and which allows for increased proliferation of the virus within the CNS by attenuation of the adaptive immune response. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 08/03786-7 - Neuronal death and inflammatory response in situ in central nervous system of patients with rabies transmitted by bats
Grantee:Maria Irma Seixas Duarte
Support Opportunities: Regular Research Grants