HDL-C concentration is related to markers of absorption and of cholesterol synthesis: Study in subjects with low vs. high HDL-C

Autor(es)

Nunes, V. S. ^[1] ; Leanca, C. C. ^[1] ; Panzoldo, N. B. ^[2] ; Parra, E. ^[2] ; Cazita, P. M. ^[1] ; Nakandakare, E. R. ^[1] ; de Faria, E. C. ^[2] ; Quintao, E. C. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lipids Lab LIM10, Div Endocrinol & Metab, Hosp Clin, Fac Med Sci, BR-01246900 Sao Paulo - Brazil

^[2] State Univ Campinas UNICAMP, Dept Clin Pathol, Sch Med Sci, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinica Chimica Acta; v. 412, n. 1-2, p. 176-180, JAN 14 2011.
• Citações Web of Science: 18

Resumo

Background: The antiatherogenic functions of high density lipoprotein (HDL-C) include its role in reverse cholesterol transport, but to what extent the concentration of HDL-C interferes with the whole-body cholesterol metabolism is unknown. Therefore, we measured markers of body cholesterol synthesis (desmosterol and lathosterol) and of intestinal cholesterol absorption (campesterol and beta-sitosterol) in healthy subjects that differ according to their plasma HDL-C concentrations. Methods: Healthy participants presented either low HDL-C (<40 mg/dl, n = 33,17 male and 16 female) or high HDL-C (>60 mg/dl, n = 33, 17 male and 16 female), BMI <30 kg/m(2), were paired according to age and gender, without secondary factors that might interfere with their plasma lipid concentrations. Plasma concentrations of non-cholesterol sterols were measured by the combined GC-MS analysis. Results: Plasma desmosterol did not differ between the two groups; however, as compared with the high HDL-C participants, the low HDL-C participants presented higher concentration of lathosterol and lower concentration of the intestinal cholesterol absorption markers campesterol and beta-sitosterol. Conclusion: Plasma concentrations of HDL, and not the activities of LCAT and CETP that regulate the reverse cholesterol transport system, correlate with plasma sterol markers of intestinal cholesterol absorption directly, and of cholesterol synthesis reciprocally. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 07/53857-5 - Concentracao plasmatica de lipoproteina de alta densidade e sua relacao com a sintese e absorcao de colesterol.
• Beneficiário: Valéria Sutti Nunes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 06/60585-9 - Relação da concentração de HDL colesterol no plasma com o metabolismo corpóreo de colesterol e em monócitos no ser humano
• Beneficiário: Eder Carlos Rocha Quintão
• Modalidade de apoio: Auxílio à Pesquisa - Temático