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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HDL-C concentration is related to markers of absorption and of cholesterol synthesis: Study in subjects with low vs. high HDL-C

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Nunes, V. S. [1] ; Leanca, C. C. [1] ; Panzoldo, N. B. [2] ; Parra, E. [2] ; Cazita, P. M. [1] ; Nakandakare, E. R. [1] ; de Faria, E. C. [2] ; Quintao, E. C. R. [1]
Total Authors: 8
[1] Univ Sao Paulo, Lipids Lab LIM10, Div Endocrinol & Metab, Hosp Clin, Fac Med Sci, BR-01246900 Sao Paulo - Brazil
[2] State Univ Campinas UNICAMP, Dept Clin Pathol, Sch Med Sci, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Clinica Chimica Acta; v. 412, n. 1-2, p. 176-180, JAN 14 2011.
Web of Science Citations: 18

Background: The antiatherogenic functions of high density lipoprotein (HDL-C) include its role in reverse cholesterol transport, but to what extent the concentration of HDL-C interferes with the whole-body cholesterol metabolism is unknown. Therefore, we measured markers of body cholesterol synthesis (desmosterol and lathosterol) and of intestinal cholesterol absorption (campesterol and beta-sitosterol) in healthy subjects that differ according to their plasma HDL-C concentrations. Methods: Healthy participants presented either low HDL-C (<40 mg/dl, n = 33,17 male and 16 female) or high HDL-C (>60 mg/dl, n = 33, 17 male and 16 female), BMI <30 kg/m(2), were paired according to age and gender, without secondary factors that might interfere with their plasma lipid concentrations. Plasma concentrations of non-cholesterol sterols were measured by the combined GC-MS analysis. Results: Plasma desmosterol did not differ between the two groups; however, as compared with the high HDL-C participants, the low HDL-C participants presented higher concentration of lathosterol and lower concentration of the intestinal cholesterol absorption markers campesterol and beta-sitosterol. Conclusion: Plasma concentrations of HDL, and not the activities of LCAT and CETP that regulate the reverse cholesterol transport system, correlate with plasma sterol markers of intestinal cholesterol absorption directly, and of cholesterol synthesis reciprocally. (C) 2010 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
Grantee:Eder Carlos Rocha Quintão
Support type: Research Projects - Thematic Grants