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Plasma concentration of HDL cholesterol in humans: relationship with whole-body cholesterol metabolism and with cholesterol metabolism in monocytes

Grant number: 09/53865-3
Support type:Multi-user Equipment Program
Duration: November 01, 2010 - October 31, 2012
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Eder Carlos Rocha Quintão
Grantee:Eder Carlos Rocha Quintão
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Tipo de equipamento: Tipo de Equipamento Multiusuário não informado
Fabricante: Fabricante não informado
Modelo: Modelo não informado

Abstract

Low plasma levels of HDL cholesterol are correlated with the incidence of cardiovascular disease in a much more significant manner than are high plasma levels of LDL cholesterol, which makes low HDL a more important risk factor. Although the mechanisms of LDL atherogenicity have been well elucidated, the exact mechanism by which HDL exerts its antiatherogenic effects remains unclear. One possibility is the involvement of HDL in reverse cholesterol transport, a system by which cholesterol from peripheral tissues, including the arterial intima, is captured by the liver and secreted into bile. The control of the whole-body cholesterol metabolism should have the following features: 1) more variation in function attributed to plasma HDL than to plasma LDL concentration; 2) blood monocytes reflecting the whole-body cholesterol synthesis; 3) cholesterol synthesis being inversely related to intestinal cholesterol absorption. Given these premises this proposal aims at determining the relationship between plasma HDL concentration and whole body cholesterol storage in blood monocytes and plasma markers of non-cholesterol synthesis and absorption sterols. Given these premises, this proposal is aimed at determining the relationship between plasma HDL concentrations and whole-body cholesterol storage. (AU)