Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs

Autor(es)

Vieira, Eveline Bis ^[1] ; Menescal-de-Oliveira, Leda ^[2] ; Andrade Leite-Panissi, Christie Ramos ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Psychobiol Postgrad Program, Sch Philosophy Sci & Literature Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Physiol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Morphol Stomatol & Physiol, Dent Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 216, n. 1, p. 94-99, JAN 1 2011.
• Citações Web of Science: 18

Resumo

Tonic immobility behavior (TI) is an innate response characterized by profound motor inhibition that is exhibited by prey when physical contact with a predator is prolonged and the situation inescapable. The periaqueductal gray matter (PAG) is intimately associated with the somatic and autonomic components of defensive reactions. This study investigated whether the TI response was able to recruit specific functional columns of the PAG by examining c-fos immunolocalization in guinea pigs. In the TI group, the innate response was invoked in animals through inversion and physical contention for at least 15 min. In the control group, the animals were physically manipulated only. Our results demonstrate that the defensive behavior of TI is capable of promoting the expression of Fos protein in different areas of the PAG, with higher levels of staining in the ventrolateral (vI) and lateral (I) columns. In addition, our results demonstrate increased Fos immunoreactivity (FOS-IR) in the dorsal raphe nucleus, the Edinger-Westphal nucleus, the cuneiform nucleus and the superior colliculus. In contrast, there were no significant alterations in the number of FOS-IR cells in the inferior colliculus or the oculomotor nucleus. Analysis of the results suggests that neuronal activation after the TI response differs by functional column of the PAG. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 04/09642-6 - Avaliação do sistema serotoninérgico do núcleo basolateral da amígdala na modulação do comportamento defensivo de imobilidade tônica em cobaias
• Beneficiário: Aline Aparecida Ferrarese Tiballi
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 05/00096-1 - Avaliação anátomo-funcional do comportamento defensivo de imobilidade tônica em cobaias
• Beneficiário: Christie Ramos Andrade Leite Panissi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/06549-3 - Avaliação do comportamento defensivo de imobilidade tônica e da nocicepção após lesões restritas em estruturas do sistema cerebral aversivo.
• Beneficiário: Eveline Bis Vieira Rasteli
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 07/08122-7 - Via HO-CO-cGMP na antinocicepção induzida por estresse em ratos
• Beneficiário: Christie Ramos Andrade Leite Panissi
• Modalidade de apoio: Auxílio à Pesquisa - Regular