Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: Multiple-domain deficits and longitudinal evaluation

Autor(es)

Ayres, Adriana de Mello ^[1] ; Scazufca, Marcia ^[1] ; Menezes, Paulo Rossi ^[2] ; Nakano, Eduardo Yoshio ^[3] ; Regina, Ana Carolina B. ^[1] ; Schaufelberger, Maristela S. ^[1] ; Murray, Robin M. ^[4] ; McGuire, Philip K. ^[4] ; Rushe, Teresa ^[5] ; Busatto, Geraldo F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Psychiat, BR-09500900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Prevent Med, BR-09500900 Sao Paulo - Brazil

^[3] Univ Brasilia, Dept Stat, Brasilia, DF - Brazil

^[4] Univ London, Inst Psychiat, London - England

^[5] Univ London, Sch Psychol, London - England

• Tipo de documento: Artigo Científico
• Fonte: PSYCHIATRY RESEARCH; v. 179, n. 2, p. 157-164, SEP 30 2010.
• Citações Web of Science: 12

Resumo

Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they progress uniformly over time in schizophrenia and affective psychoses. We applied 12 tests organized into eight cognitive domains, comparing psychosis patients (n = 56, time from initial contact = 677.95+/-183.27 days) versus healthy controls (n = 70) recruited from the same area of Sao Paulo, Brazil. Longitudinal comparisons (digit span and verbal fluency) were conducted between a previous assessment of the subjects carried out at their psychosis onset, and the current follow-up evaluation. Psychosis patients differed significantly from controls on five domains, most prominently on verbal memory. Cognitive deficits remained detectable in separate comparisons of the schizophrenia subgroup and, to a lesser extent, the affective psychosis subjects against controls. Longitudinal comparisons indicated significant improvement in schizophrenia, affective psychoses, and control subjects, with no significant group-by-time interactions. Our results reinforce the view that there are generalized cognitive deficits in association with recent-onset psychoses, particularly of non-affective nature, which persist over time. (C) 2009 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 03/13627-0 - Seguimento de pacientes portadores de psicoses funcionais um ano após o primeiro contato com serviços de saúde: prognóstico, aspectos de neuroimagem, uso de serviços e sobrecarga em cuidadores informais
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular