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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: Multiple-domain deficits and longitudinal evaluation

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Author(s):
Ayres, Adriana de Mello [1] ; Scazufca, Marcia [1] ; Menezes, Paulo Rossi [2] ; Nakano, Eduardo Yoshio [3] ; Regina, Ana Carolina B. [1] ; Schaufelberger, Maristela S. [1] ; Murray, Robin M. [4] ; McGuire, Philip K. [4] ; Rushe, Teresa [5] ; Busatto, Geraldo F. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Psychiat, BR-09500900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Prevent Med, BR-09500900 Sao Paulo - Brazil
[3] Univ Brasilia, Dept Stat, Brasilia, DF - Brazil
[4] Univ London, Inst Psychiat, London - England
[5] Univ London, Sch Psychol, London - England
Total Affiliations: 5
Document type: Journal article
Source: PSYCHIATRY RESEARCH; v. 179, n. 2, p. 157-164, SEP 30 2010.
Web of Science Citations: 12
Abstract

Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they progress uniformly over time in schizophrenia and affective psychoses. We applied 12 tests organized into eight cognitive domains, comparing psychosis patients (n = 56, time from initial contact = 677.95+/-183.27 days) versus healthy controls (n = 70) recruited from the same area of Sao Paulo, Brazil. Longitudinal comparisons (digit span and verbal fluency) were conducted between a previous assessment of the subjects carried out at their psychosis onset, and the current follow-up evaluation. Psychosis patients differed significantly from controls on five domains, most prominently on verbal memory. Cognitive deficits remained detectable in separate comparisons of the schizophrenia subgroup and, to a lesser extent, the affective psychosis subjects against controls. Longitudinal comparisons indicated significant improvement in schizophrenia, affective psychoses, and control subjects, with no significant group-by-time interactions. Our results reinforce the view that there are generalized cognitive deficits in association with recent-onset psychoses, particularly of non-affective nature, which persist over time. (C) 2009 Elsevier Ireland Ltd. All rights reserved. (AU)