Electronegative Low-Density Lipoprotein is Associated with Dense Low-Density Lipoprotein in Subjects with Different Levels of Cardiovascular Risk

Autor(es)

de Queiroz Mello, Ana Paula ^[1] ; da Silva, Isis Tande ^[1] ; Oliveira, Aline Silva ^[1] ; Nunes, Valeria Sutti ^[2] ; Parra Abdalla, Dulcineia Saes ^[3] ; Gidlund, Magnus ^[4] ; Teixeira Damasceno, Nagila Raquel ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Fac Saude Publ, BR-01246904 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Lipids Lab LIM 10, Sch Med, BR-01246904 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Clin & Toxicol Anal, Sch Pharmaceut Sci, BR-01246904 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-01246904 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: LIPIDS; v. 45, n. 7, p. 619-625, JUL 2010.
• Citações Web of Science: 10

Resumo

Dyslipidemias and physicochemical changes in low-density lipoprotein (LDL) are very important factors for the development of coronary artery disease (CAD). However, pathophysiological properties of electronegative low-density lipoprotein {[}LDL(-)] remain a controversial issue. Our objective was to investigate LDL(-) content in LDL and its subfractions (phenotypes A and B) of subjects with different cardiovascular risk. Seventy-three subjects were randomized into three groups: normolipidemic (N; n = 30) and hypercholesterolemic (HC; n = 33) subjects and patients with CAD (n = 10). After fasting, blood samples were collected and total, dense and light LDL were isolated. LDL(-) content in total LDL and its subfractions was determined by ELISA. LDL(-) content in total LDL was lower in the N group as compared to the HC (P < 0.001) and CAD (P = 0.006) groups. In the total sample and in those of the N, HC, and CAD groups, LDL(-) content in dense LDL was higher than in light LDL (P = 0.001, 0.001, 0.001, and 0.033, respectively) The impact of LDL(-) on cardiovascular risk was reinforced when LDL(-) content in LDL showed itself to have a positive association with total cholesterol (beta = 0.003; P < 0.001), LDL-C (beta = 0.003; p < 0.001), and non-HDL-C (beta = 0.003; P < 0.001) and a negative association with HDL-C (beta = -0.32; P = 0.04). Therefore, LDL(-) is an important biomarker that showed association with the lipid profile and the level of cardiovascular risk. (AU)

• Processo FAPESP: 04/11792-6 - Influência do perfil nutricional sobre a geração de LDL- nas dislipidemias isoladas ou associadas aos eventos cardiovasculares
• Beneficiário: Nágila Raquel Teixeira Damasceno
• Modalidade de apoio: Auxílio à Pesquisa - Regular