Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents

Autor(es)

Rando, Daniela Goncalves ^[1] ; Giarolla, Jeanine ^[1] ; Mesquita Pasqualoto, Kerly Fernanda ^[1] ; Ferreira, Elizabeth Igne ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Lab Design & Synth Chemotherapeut Agents Potentia, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 46, n. 2, p. 311-321, APR-JUN 2010.
• Citações Web of Science: 3

Resumo

Leishmaniasis is an important health and social problem for which there is limited effective therapy. Chalcones and N-acylhydrazones have been studied as promising antileishmanial agents in enzymatic inhibition and in vitro assays. Since these chemical classes of compounds also resemble each other structurally, it would be useful to investigate whether they share direct analogy. Exploratory data analysis was applied to a library of chalcones and nitrated N-acylhydrazones assayed against Leishmania donovani to investigate their similarity. Under the conditions applied in the present study, the two classes did not present functional or structural analogy. (AU)

• Processo FAPESP: 06/00116-5 - Chalconas e N-acilidrazonas bioativas: análise estrutural comparativa por meio de estudos de QSAR e desenvolvimento de análogos otimizados
• Beneficiário: Daniela Goncales Galasse Rando
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 01/01192-3 - Antichagásicos potenciais derivados de compostos nitro-heterocíclicos
• Beneficiário: Elizabeth Igne Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Temático