| Texto completo | |
| Autor(es): |
Song Watanabe, Sung Eun
[1]
;
Berezovsky, Adriana
[1]
;
Motono, Marcia
[1]
;
Sacai, Paula Yuri
[1]
;
Pereira, Josenilson Martins
[1]
;
Ferraz Sallum, Juliana Maria
[1]
;
Gebrim, Luiz Henrique
[2]
;
Salomao, Solange Rios
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Discipline Mastol, Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | DOCUMENTA OPHTHALMOLOGICA; v. 120, n. 2, p. 137-143, APR 2010. |
| Citações Web of Science: | 6 |
| Resumo | |
Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. The purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen-14 females (47-72 years, mean 58.3 +/- A 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment-10 females (39-65 years, mean 50.1 +/- A 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control-13 normal female volunteers (41-81 years, mean 52.7 +/- A 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed. Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer. (AU) | |
| Processo FAPESP: | 01/03364-6 - Avaliacao funcional de toxicidade retiniana em pacientes com cancer de mama tratados com baixa dosagem de tamoxifeno. |
| Beneficiário: | Solange Rios Salomão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |