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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Retinal function in patients treated with tamoxifen

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Author(s):
Song Watanabe, Sung Eun [1] ; Berezovsky, Adriana [1] ; Motono, Marcia [1] ; Sacai, Paula Yuri [1] ; Pereira, Josenilson Martins [1] ; Ferraz Sallum, Juliana Maria [1] ; Gebrim, Luiz Henrique [2] ; Salomao, Solange Rios [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Discipline Mastol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: DOCUMENTA OPHTHALMOLOGICA; v. 120, n. 2, p. 137-143, APR 2010.
Web of Science Citations: 6
Abstract

Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. The purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen-14 females (47-72 years, mean 58.3 +/- A 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment-10 females (39-65 years, mean 50.1 +/- A 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control-13 normal female volunteers (41-81 years, mean 52.7 +/- A 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed. Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer. (AU)