Protein synthesis regulation by leucine

Autor(es)

Vianna, Daiana ; Resende Teodoro, Gabriela Fullin ; Torres-Leal, Francisco Leonardo ^[1] ; Tirapegui, Julio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Food Sci & Expt Nutr, Fac Pharmaceut Sci, PRONUT, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 46, n. 1, p. 29-36, JAN-MAR 2010.
• Citações Web of Science: 6

Resumo

In vivo and in vitro studies have demonstrated that high protein diets affect both protein synthesis and regulation of several cellular processes. The role of amino acids as substrate for protein synthesis has been established in the literature. However, the mechanism by which these amino acids modulate transcription and regulate the mRNA translation via mTOR-dependent signaling pathway has yet to be fully determined. It has been verified that mTOR is a protein responsible for activating a cascade of biochemical intracellular events which result in the activation of the protein translation process. Of the aminoacids, leucine is the most effective in stimulating protein synthesis and reducing proteolysis. Therefore, it promotes a positive nitrogen balance, possibly by favoring the activation of this protein. This amino acid also directly and indirectly stimulates the synthesis and secretion of insulin, enhancing its anabolic cellular effects. Therefore, this review aimed to identify the role of leucine in protein synthesis modulation and to discuss the metabolic aspects related to this aminoacid. (AU)

• Processo FAPESP: 07/56230-3 - Efeitos da suplementação crônica com leucina na composição corporal durante o envelhecimento: estudos em ratos
• Beneficiário: Julio Orlando Tirapegui Toledo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/59291-3 - Efeitos da suplementação com leucina e do exercício físico sobre a composição corporal e as concentrações séricas de adipocinas em ratos previamente submetidos a uma dieta hiperlipídica
• Beneficiário: Julio Orlando Tirapegui Toledo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/51964-9 - Suplementacao com leucina nao reproduz os efeitos beneficos do exercicio fisico sobre a adiposidade e a homeostase glicemica de ratos apos dieta hiperlipidica.
• Beneficiário: Francisco Leonardo Torres Leal
• Modalidade de apoio: Bolsas no Brasil - Mestrado