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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Protein synthesis regulation by leucine

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Author(s):
Vianna, Daiana ; Resende Teodoro, Gabriela Fullin ; Torres-Leal, Francisco Leonardo [1] ; Tirapegui, Julio [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Dept Food Sci & Expt Nutr, Fac Pharmaceut Sci, PRONUT, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Brazilian Journal of Pharmaceutical Sciences; v. 46, n. 1, p. 29-36, JAN-MAR 2010.
Web of Science Citations: 6
Abstract

In vivo and in vitro studies have demonstrated that high protein diets affect both protein synthesis and regulation of several cellular processes. The role of amino acids as substrate for protein synthesis has been established in the literature. However, the mechanism by which these amino acids modulate transcription and regulate the mRNA translation via mTOR-dependent signaling pathway has yet to be fully determined. It has been verified that mTOR is a protein responsible for activating a cascade of biochemical intracellular events which result in the activation of the protein translation process. Of the aminoacids, leucine is the most effective in stimulating protein synthesis and reducing proteolysis. Therefore, it promotes a positive nitrogen balance, possibly by favoring the activation of this protein. This amino acid also directly and indirectly stimulates the synthesis and secretion of insulin, enhancing its anabolic cellular effects. Therefore, this review aimed to identify the role of leucine in protein synthesis modulation and to discuss the metabolic aspects related to this aminoacid. (AU)