Evaluation of the Effect of Tumor Necrosis Factor-Alpha Gene Polymorphism on the Risk of Peri-implantitis: A Case-Control Study

Autor(es)

Cury, Patricia R. ^[1] ; Horewicz, Veronica V. ^[2] ; Ferrari, Daniel S. ^[1] ; Brito, Jr., Rui ^[3] ; Sendyk, Wilson R. ^[1] ; Duarte, Poliana M. ^[4] ; Shibli, Jamil A. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Santo Amaro, Dept Periodontol & Implantol, Sch Dent, Santo Amaro - Brazil

^[2] Univ Fed Bahia, Sch Dent, Res Grp Periodontal Dis, Dept Periodont, BR-41170290 Salvador, BA - Brazil

^[3] Sao Leopoldo Mand Dent Res Ctr, Dept Histol, Sao Paulo - Brazil

^[4] Univ Guarulhos, Dept Periodontol, Dent Res Div, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS; v. 24, n. 6, p. 1101-1105, NOV-DEC 2009.
• Citações Web of Science: 16

Resumo

Purpose: Tumor necrosis factor-alpha (TNF alpha) is a proinflammatory cytokine, which promotes bone resorption and mediates the inflammatory response to infection. Because implant failures appear to cluster in subsets of individuals, this phenomenon may be related to gene polymorphisms. Therefore, the aim of this study was to investigate the relationship between a specific polymorphism in the TNF alpha gene (allele 2 of TNF alpha(-308)) and peri-implantitis. Materials and Methods: This case-control study included Caucasian nonsmoking Brazilian patients with implant-supported restorations. Oral epithelial cells were taken from patients with and without peri-implantitis to evaluate the frequencies of different alleles of the TNF alpha(-308) gene by polymerase chain reaction. Results: Ninety patients (49 with peri-implantitis and 41 with healthy implants) were enrolled in this study. Polymorphism in allele 2 of TNF alpha(-308) was not associated with an increased risk for peri-implantitis (P = .8171), although 14.63% of the subjects in the control group carried allele 2 and 19.39% in the peri-implantitis group carried allele 2 (chi-squared = 0.708; P = .5202). Conclusion: Polymorphism of the TNF alpha(-308) gene was not associated with an increased risk of peri-implantitis in the population evaluated in this study. INT J ORAL MAXILLOFAC IMPLANTS 2009;24:1101-1105 (AU)

• Processo FAPESP: 05/01939-2 - Metronidazol associado à amoxicilina no tratamento das peri-implantites
• Beneficiário: Jamil Awad Shibli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/03557-0 - Avaliacao longitudinal da utilizacao do metronidazol associado a amoxicilina no tratamento das peri-implantites.
• Beneficiário: Daniel Sanchez Ferrari
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 06/01396-1 - Efeitos de bacterias da microbiota periodontal no fenotipo e funcao das celulas dendriticas de individuos com periodontite cronica ou saudaveis.
• Beneficiário: Verônica Vargas Horewicz
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 05/60193-0 - Efeitos de bacterias da microbiota periodontal na funcao das celulas dendriticas humanas in vitro.
• Beneficiário: Angela de Oliveira Augusto
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 03/05023-7 - Avaliação dos parâmentros clínicos, microbiológicos e imunológicos de implantes osseointegrados
• Beneficiário: Jamil Awad Shibli
• Modalidade de apoio: Auxílio à Pesquisa - Regular