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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Evaluation of the Effect of Tumor Necrosis Factor-Alpha Gene Polymorphism on the Risk of Peri-implantitis: A Case-Control Study

Autor(es):
Cury, Patricia R. [1] ; Horewicz, Veronica V. [2] ; Ferrari, Daniel S. [1] ; Brito, Jr., Rui [3] ; Sendyk, Wilson R. [1] ; Duarte, Poliana M. [4] ; Shibli, Jamil A. [4]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Santo Amaro, Dept Periodontol & Implantol, Sch Dent, Santo Amaro - Brazil
[2] Univ Fed Bahia, Sch Dent, Res Grp Periodontal Dis, Dept Periodont, BR-41170290 Salvador, BA - Brazil
[3] Sao Leopoldo Mand Dent Res Ctr, Dept Histol, Sao Paulo - Brazil
[4] Univ Guarulhos, Dept Periodontol, Dent Res Div, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS; v. 24, n. 6, p. 1101-1105, NOV-DEC 2009.
Citações Web of Science: 16
Resumo

Purpose: Tumor necrosis factor-alpha (TNF alpha) is a proinflammatory cytokine, which promotes bone resorption and mediates the inflammatory response to infection. Because implant failures appear to cluster in subsets of individuals, this phenomenon may be related to gene polymorphisms. Therefore, the aim of this study was to investigate the relationship between a specific polymorphism in the TNF alpha gene (allele 2 of TNF alpha(-308)) and peri-implantitis. Materials and Methods: This case-control study included Caucasian nonsmoking Brazilian patients with implant-supported restorations. Oral epithelial cells were taken from patients with and without peri-implantitis to evaluate the frequencies of different alleles of the TNF alpha(-308) gene by polymerase chain reaction. Results: Ninety patients (49 with peri-implantitis and 41 with healthy implants) were enrolled in this study. Polymorphism in allele 2 of TNF alpha(-308) was not associated with an increased risk for peri-implantitis (P = .8171), although 14.63% of the subjects in the control group carried allele 2 and 19.39% in the peri-implantitis group carried allele 2 (chi-squared = 0.708; P = .5202). Conclusion: Polymorphism of the TNF alpha(-308) gene was not associated with an increased risk of peri-implantitis in the population evaluated in this study. INT J ORAL MAXILLOFAC IMPLANTS 2009;24:1101-1105 (AU)

Processo FAPESP: 03/05023-7 - Avaliação dos parâmentros clínicos, microbiológicos e imunológicos de implantes osseointegrados
Beneficiário:Jamil Awad Shibli
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 05/03557-0 - Avaliacao longitudinal da utilizacao do metronidazol associado a amoxicilina no tratamento das peri-implantites.
Beneficiário:Daniel Sanchez Ferrari
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 05/01939-2 - Metronidazol associado à amoxicilina no tratamento das peri-implantites
Beneficiário:Jamil Awad Shibli
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 05/60193-0 - Efeitos de bacterias da microbiota periodontal na funcao das celulas dendriticas humanas in vitro.
Beneficiário:Angela de Oliveira Augusto
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 06/01396-1 - Efeitos de bacterias da microbiota periodontal no fenotipo e funcao das celulas dendriticas de individuos com periodontite cronica ou saudaveis.
Beneficiário:Verônica Vargas Horewicz
Linha de fomento: Bolsas no Brasil - Mestrado