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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of the Effect of Tumor Necrosis Factor-Alpha Gene Polymorphism on the Risk of Peri-implantitis: A Case-Control Study

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Author(s):
Cury, Patricia R. [1] ; Horewicz, Veronica V. [2] ; Ferrari, Daniel S. [1] ; Brito, Jr., Rui [3] ; Sendyk, Wilson R. [1] ; Duarte, Poliana M. [4] ; Shibli, Jamil A. [4]
Total Authors: 7
Affiliation:
[1] Univ Santo Amaro, Dept Periodontol & Implantol, Sch Dent, Santo Amaro - Brazil
[2] Univ Fed Bahia, Sch Dent, Res Grp Periodontal Dis, Dept Periodont, BR-41170290 Salvador, BA - Brazil
[3] Sao Leopoldo Mand Dent Res Ctr, Dept Histol, Sao Paulo - Brazil
[4] Univ Guarulhos, Dept Periodontol, Dent Res Div, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS; v. 24, n. 6, p. 1101-1105, NOV-DEC 2009.
Web of Science Citations: 16
Abstract

Purpose: Tumor necrosis factor-alpha (TNF alpha) is a proinflammatory cytokine, which promotes bone resorption and mediates the inflammatory response to infection. Because implant failures appear to cluster in subsets of individuals, this phenomenon may be related to gene polymorphisms. Therefore, the aim of this study was to investigate the relationship between a specific polymorphism in the TNF alpha gene (allele 2 of TNF alpha(-308)) and peri-implantitis. Materials and Methods: This case-control study included Caucasian nonsmoking Brazilian patients with implant-supported restorations. Oral epithelial cells were taken from patients with and without peri-implantitis to evaluate the frequencies of different alleles of the TNF alpha(-308) gene by polymerase chain reaction. Results: Ninety patients (49 with peri-implantitis and 41 with healthy implants) were enrolled in this study. Polymorphism in allele 2 of TNF alpha(-308) was not associated with an increased risk for peri-implantitis (P = .8171), although 14.63% of the subjects in the control group carried allele 2 and 19.39% in the peri-implantitis group carried allele 2 (chi-squared = 0.708; P = .5202). Conclusion: Polymorphism of the TNF alpha(-308) gene was not associated with an increased risk of peri-implantitis in the population evaluated in this study. INT J ORAL MAXILLOFAC IMPLANTS 2009;24:1101-1105 (AU)

FAPESP's process: 05/01939-2 - Metronidazole associated with amoxicillin in the treatment of peri-implantitis
Grantee:Jamil Awad Shibli
Support Opportunities: Regular Research Grants