Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

Autor(es)

Santos, Edson Lucas ^[1] ; Souza, Kely de Picoli ^[1] ; da Silva, Elton Dias ^[2] ; Batista, Elice Carneiro ^[2] ; Forcina Martins, Paulo J. ^[3] ; D'Almeida, Vania ^[3] ; Pesquero, Joao Bosco ^[2]

Afiliação do(s) autor(es)

^[1] Fed Univ Grande Dourados, Sch Environm & Biol Sci, Dourados, MS - Brazil

^[2] Univ Fed Sao Paulo, Dept Biophys, BR-04023062 Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Psychobiol, BR-04023062 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Biochemical Pharmacology; v. 78, n. 8, p. 951-958, OCT 15 2009.
• Citações Web of Science: 58

Resumo

Renin-angiotensin system is involved in homeostasis processes linked to renal and cardiovascular system and recently has been linked to metabolic syndrome. We analyzed the influence of long term angiotensin I converting enzyme (ACE) inhibitor enalapril treatment in normotensive adult Wistar rats fed with standard or palatable hyperlipidic diets. Our results show that long term enalapril treatment decreases absolute food intake, serum leptin concentration and body weight gain. Moreover, in adipose tissue, enalapril treatment led to decreased ACE activity, enhanced the expression of peroxisome proliferator activated receptor gamma, adiponectin, hormone-sensitive lipase, fatty acid synthase, catalase and superoxide dismutase resulting in prolonged life span. On the other hand, the ACE inhibitor was not able to improve the transport of leptin through the blood brain barrier or to alter the sensitivity of this hormone in the central nervous system. The effect of enalapril in decreasing body weight gain was also observed in older rats. In summary, these results extend our previous findings and corroborate data from the literature regarding the beneficial metabolic effects of enalapril and show for the first time that this ACE inhibitor prolongs life span in rats also fed with palatable hyperlipidic diet, an action probably correlated with adipose tissue metabolic modulation and body weight reduction. (C) 2009 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 02/00807-7 - Biologia molecular dos sistemas renina-angiotensina e calicreínas cininas
• Beneficiário: João Bosco Pesquero
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/07715-6 - Analise estrutural e funcional do receptor b1 de cininas e sua dimerizacao com o receptor at1 da angiotensina.
• Beneficiário: Edson Lucas dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado