Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca

Autor(es)

Barreto, S. A. ^[1] ; Chaguri, L. C. A. G. ^[1] ; Prezoto, B. C. ^[2] ; Lebrun, I. ^[1]

Afiliação do(s) autor(es)

^[1] Butantan Inst, Biochem & Biophys Lab, BR-05503900 Sao Paulo - Brazil

^[2] Butantan Inst, Pharmacol Lab, BR-05503900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 149, n. 4, p. 552-558, MAY 2009.
• Citações Web of Science: 3

Resumo

Incubation of plasma from the snake Bothrops jararaca (BJP) with trypsin generated two hypotensive peptides. The primary structure of the peptides was established for three sequences as: Asn-Pro-Phe-Val-Asp-Ala (fraction 13), Set-Lys-Pro-Asn-Met-Ser-Asp-Glu-Ser-Leu-Ala-Val-Ala-Ile (fraction 14), Asn-Pro-Phe-Val-Asp-Ala (fraction 15). These peptides display homology with fragments of albumin from Trimeresurus flavoviridis. A bolus intra-arterial injection of the purified or the synthetic peptide produced a strong and sustained vasopressor response in the anaesthetized snake B. jararaca and Wistar rats; this hypotensive effect was also potentiated by captopril, an angioterisin-converting enzyme inhibitor (0.1 mg/kg). The natural concentrations of these peptides in plasma need to be determined and could play a physiological role in snake blood pressure regulation. (c) 2009 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 03/09312-3 - Obtenção de peptídeos vasoativos a partir do plasma de serpentes brasileiras (Bothrops jararaca, Crotalus durissus terrificus e Waglerophis merremii)
• Beneficiário: Sandra Alves Barreto Barbosa
• Modalidade de apoio: Bolsas no Brasil - Mestrado