Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca

Barreto, S. A.; Chaguri, L. C. A. G.; Prezoto, B. C.; Lebrun, I.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca

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Author(s):	Barreto, S. A. ^[1] ; Chaguri, L. C. A. G. ^[1] ; Prezoto, B. C. ^[2] ; Lebrun, I. ^[1] Total Authors: 4
Affiliation:	^[1] Butantan Inst, Biochem & Biophys Lab, BR-05503900 Sao Paulo - Brazil ^[2] Butantan Inst, Pharmacol Lab, BR-05503900 Sao Paulo - Brazil Total Affiliations: 2
Document type:	Journal article
Source:	COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 149, n. 4, p. 552-558, MAY 2009.
Web of Science Citations:	3
Abstract
Incubation of plasma from the snake Bothrops jararaca (BJP) with trypsin generated two hypotensive peptides. The primary structure of the peptides was established for three sequences as: Asn-Pro-Phe-Val-Asp-Ala (fraction 13), Set-Lys-Pro-Asn-Met-Ser-Asp-Glu-Ser-Leu-Ala-Val-Ala-Ile (fraction 14), Asn-Pro-Phe-Val-Asp-Ala (fraction 15). These peptides display homology with fragments of albumin from Trimeresurus flavoviridis. A bolus intra-arterial injection of the purified or the synthetic peptide produced a strong and sustained vasopressor response in the anaesthetized snake B. jararaca and Wistar rats; this hypotensive effect was also potentiated by captopril, an angioterisin-converting enzyme inhibitor (0.1 mg/kg). The natural concentrations of these peptides in plasma need to be determined and could play a physiological role in snake blood pressure regulation. (c) 2009 Elsevier Inc. All rights reserved. (AU)

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