3q27 Aberrations in a Childhood Ovary Teratoma With Associated Malignant Germ Cell Component

Autor(es)

Brassesco, Maria Sol ^[1] ; Castro-Gamero, Angel Mauricio ^[2] ; Valera, Elvis Terci ^[1] ; Neder, Luciano ^[3] ; Elias, Jr., Jorge ; Tone, Luiz Gonzaga ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Radiol, Dept Pediat, Div Pediat Oncol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC BLOOD & CANCER; v. 52, n. 3, p. 398-401, MAR 2009.
• Citações Web of Science: 3

Resumo

Cytogenetic Studies of childhood ovary tumors have been poorly described. in the present article, the cytogenetic findings of an ovarian teratoma with malignant germ cell (yolk-sac) component occurring in an 8-year-old female are detailed. GTG-banding showed a karyotype of 46,XX, t(3;20)(q27;q13.3) {[}4]/46,XX, del3q27 {[}3]/46,XX {[}30]. Previous Studies have demonstrated common sites of loss of heterozygosity at 3q27-q28 region in different types of cancer, suggesting the presence of tumor Suppressor genes within this region. Pediatr Blood Cancer 2009;52:398-401. (C) 2008 Wiley-Liss, Inc. (AU)

• Processo FAPESP: 07/54236-4 - Analise do perfil genomico em neoplasias da infancia atraves da hibridizacao genomica comparativa.
• Beneficiário: Luiz Gonzaga Tone
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/04827-3 - Análise de aneuploidias por hibridação genômica comparativa (CGH) em pacientes pediátricos portadores de leucemia linfóide aguda
• Beneficiário: María Sol Brassesco Annichini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado