Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The Estrous Cycle Modulates Small Leucine-Rich Proteoglycans Expression in Mouse Uterine Tissues

Texto completo
Autor(es):
Salgado, Renato M. ; Favaro, Rodolfo R. ; Martin, Sebastian San [1] ; Zorn, Telma M. T. [2]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Valparaiso, Fac Med, Ctr Invest & Biol Reprod, Valparaiso - Chile
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Lab Reprod & Extracellular Matrix Biol, ICB, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology; v. 292, n. 1, p. 138-153, JAN 2009.
Citações Web of Science: 20
Resumo

In the pregnant mouse uterus, small leucine-rich proteoglycans (SLRPs) are drastically remodeled within a few hours after fertilization, suggesting that ovarian hormone levels modulate their synthesis and degradation. In this study, we followed by immunoperoxidase approach, the presence of four members of the SLRP family (decorin, lumican, biglycan, and fibromodulin) in the uterine tissues along the estrous cycle of the mouse. All molecules except fibromodulin, which predominates in the myometrium, showed a striking modulation in their distribution in the endometrial stroma, following the rise in the level of estrogen. Moreover, notable differences in the distribution of SLRPs were observed between superficial and deep stroma, as well as between the internal and external layers of the myometrium. Only biglycan and fibromodulin were expressed in the luminal and glandular epithelia. All four SLRPs were found in cytoplasmic granules of mononucleated cells. The pattern of distribution of the immunoreaction for these molecules in the uterine tissues was found to be estrous cycle-stage dependent, suggesting that these molecules undergo ovarian hormonal control and probably participate in the preparation of the uterus for decidualization and embryo implantation. In addition, this and previous results from our laboratory suggest the existence of two subpopulations of endometrial fibroblasts that may be related to the centrifugal development of the decidua. Anat Rec, 292:138-153, 2009. (c) 2008 Wiley-Liss, Inc. (AU)

Processo FAPESP: 04/09947-1 - Caracterização de proteoglicanos do endométrio de camundongos durante o ciclo estral e em animais ovarectomizados: análise dos efeitos da castração e da reposição hormonal
Beneficiário:Renato de Mayrinck Salgado
Linha de fomento: Bolsas no Brasil - Doutorado Direto