Cyhalothrin increased c-fos immunoreactivity at the paraventricular nucleus of the hypothalamus in rats, and suppressed macrophage activity in an adrenal-dependent fashion

Autor(es)

Righi, D. A. ^[1] ; Xavier, F. G. ^[2] ; Palermo-Neto, J. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Brasilia, Sch Hlth Sci, Mol Pharmacol Lab, Dept Pharmaceut Sci, Brasilia, DF - Brazil

^[2] Univ Sao Paulo, Sch Vet Med, Appl Pharmacol & Toxicol Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 27, n. 1, p. 96-102, JAN 2009.
• Citações Web of Science: 3

Resumo

Synthetic type II pyrethroid insecticides, such as cyhalothrin at certain dosage levels, simultaneously induce stress-like symptoms and innate immunosuppressive effects in laboratory animals. The present study was designed to further analyze the stress-like effects induced by cyhalotrin and also investigate the role of Hypothalamus-Hypophysis-Adrenal (HHA) axis and Sympathetic Nervous Systems (SNS) and their effects on macrophage activity of rats. Results showed that cyhalothrin treatment (3.0 mg/kg/day. for 7 days) increased corticosterone serum levels and c-fos immunoreactivity at the paraventricular nucleus of the hypothalamus (PVN) but induced no changes in c-fos expression at the basolateral amygdala (BLA). Both areas were related to HHA axis and SNS activations by stress. Further analysis showed that adrenalectomy partially abrogated the suppression effects of cyhalothrin on macrophage activity and that 6-OHDA-induced peripheral symphatectyomy had no effects on this innate immune cell activity. The present observed data support and reinforce the notion that cyhalotrin at this treatment schedule induces stress-like symptoms and suggest that other factors, beyond indirect neuroadaptative responses, are necessary for the suppression effects of insecticide on innate immune response. (C) 2008 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 03/06538-0 - Efeitos da administração de cialotrina sobre a atividade de macrófagos peritoneais de ratos: parte II: mecanismo de ação
• Beneficiário: Dario Abbud Righi
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 04/14128-0 - Neuroimunomodulação: efeitos do estresse e de citocinas nas relações bidirecionais entre os sistemas nervosos central e imune
• Beneficiário: João Palermo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático