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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cyhalothrin increased c-fos immunoreactivity at the paraventricular nucleus of the hypothalamus in rats, and suppressed macrophage activity in an adrenal-dependent fashion

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Author(s):
Righi, D. A. [1] ; Xavier, F. G. [2] ; Palermo-Neto, J. [2]
Total Authors: 3
Affiliation:
[1] Univ Brasilia, Sch Hlth Sci, Mol Pharmacol Lab, Dept Pharmaceut Sci, Brasilia, DF - Brazil
[2] Univ Sao Paulo, Sch Vet Med, Appl Pharmacol & Toxicol Lab, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 27, n. 1, p. 96-102, JAN 2009.
Web of Science Citations: 3
Abstract

Synthetic type II pyrethroid insecticides, such as cyhalothrin at certain dosage levels, simultaneously induce stress-like symptoms and innate immunosuppressive effects in laboratory animals. The present study was designed to further analyze the stress-like effects induced by cyhalotrin and also investigate the role of Hypothalamus-Hypophysis-Adrenal (HHA) axis and Sympathetic Nervous Systems (SNS) and their effects on macrophage activity of rats. Results showed that cyhalothrin treatment (3.0 mg/kg/day. for 7 days) increased corticosterone serum levels and c-fos immunoreactivity at the paraventricular nucleus of the hypothalamus (PVN) but induced no changes in c-fos expression at the basolateral amygdala (BLA). Both areas were related to HHA axis and SNS activations by stress. Further analysis showed that adrenalectomy partially abrogated the suppression effects of cyhalothrin on macrophage activity and that 6-OHDA-induced peripheral symphatectyomy had no effects on this innate immune cell activity. The present observed data support and reinforce the notion that cyhalotrin at this treatment schedule induces stress-like symptoms and suggest that other factors, beyond indirect neuroadaptative responses, are necessary for the suppression effects of insecticide on innate immune response. (C) 2008 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 04/14128-0 - Neuroimmunomodulation: effects of drugs, stress and cytocines on central nervous and immune systems bidirectional relationships
Grantee:João Palermo Neto
Support Opportunities: Research Projects - Thematic Grants