IGF-I and INS receptor expression in the salivary glands of diabetic Nod mice submitted to long-term insulin treatment

Autor(es)

Caldeira, Eduardo Jose ^[1] ; Alves Cagnon, Valeria Helena ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Anat, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Cell Biology International; v. 32, n. 1, p. 16-21, JAN 2008.
• Citações Web of Science: 9

Resumo

This work aimed to characterize the IGF-I and INS receptor expression in the salivary glands of Nod mice, correlating to therapeutic effects of insulin treatment on these receptors. Nod mice were divided into: Groups 1 and 2 (diabetic), Groups 3 and 4 (diabetic with insulin treatment) and Group 5 (non-diabetic). Fragments from the salivary glands were processed for immunohistochemical analysis. The results showed that the prolonged diabetic state led to a steadily increased IGF-I receptor expression. INS receptor expression was gradually decreased. It was concluded that not only was the IGF-I receptor expression affected by the diabetic state but also the INS receptor expression. The period of the diabetic state was directly related to changes in the expression of these receptors. In spite of the insulin treatment having recovered the glycaemic levels, the expression of INS and the IGF-I receptors did not reach the standard level, which certainly hampered glandular function. (C) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 03/13377-3 - Expressao de insr e igf-1r em glandulas salivares de camundongos espontaneamente diabeticos apos tratamento glicemico prolongado.
• Beneficiário: Valéria Helena Alves Cagnon Quitete
• Modalidade de apoio: Auxílio à Pesquisa - Regular