Identification of a bioactive compound isolated from Brazilian propolis type 6

Autor(es)

Castro, Myrella Lessio ^[1] ; do Nascimento, Andrea Mendes ^[2] ; Ikegaki, Masaharu ^[3] ; Costa-Neto, Claudio M. ^[4] ; Alencar, Severino M. ^[2] ; Rosalen, Pedro L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Physiol Sci, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP - Brazil

^[2] Univ Sao Paulo, Dept Agri Food Ind Food & Nutr, Luiz de Queiroz Coll Agr, BR-13418900 Piracicaba, SP - Brazil

^[3] Univ Fed Alfenas, Dept Pharm, BR-37130000 Alfenas, MG - Brazil

^[4] Univ Sao Paulo, Dept Biochem & Immunol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Bioorganic & Medicinal Chemistry; v. 17, n. 14, p. 5332-5335, JUL 15 2009.
• Citações Web of Science: 32

Resumo

A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50) = 0.1756 mu M), strong antimicrobial activity (MIC range-0.73-6.6 mu g/mL; MBC range-2.92-106 mu g/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 04/08635-6 - Isolamento e identificação de compostos bioativos de uma nova variedade de própolis brasileira produzida por abelhas da espécie Apis mellifera
• Beneficiário: Severino Matias de Alencar
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores