Local secretion/shedding of tumor-derived CD83 molecules as a novel tumor escape mechanism

Autor(es)

Baleeiro‚ RB ; Barbuto‚ JAM

• Tipo de documento: Artigo Científico
• Fonte: Molecular Immunology; v. 45, n. 12, p. 3502-3504, 2008.

Resumo

CD83, a characteristic marker of activated dendritic cells, is also expressed by tumor cell lines from various origins and by primary lung cancers. Here, we show that CD83+ tumor cells (from a primary lung cancer and from an established breast cancer cell line) release in their culture supernatants a soluble factor that is able to block, in a dose-dependent manner, CD4+ and CD8+ T cell proliferative responses to allogeneic dendritic cells. This factor was removed from the medium by incubation in anti-CD83 covered plates, indicating that it could be one of the known soluble forms of the CD83 molecule, released in the medium by the cultured tumor cells. This phenomenon, happening in vivo, in the tumor microenvironment, could affect profoundly anti-tumor immune responses and should, therefore, be considered in immunotherapeutic approaches to cancer. (C) 2008 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 05/50422-2 - Estudo da expressao de citocinas no microambiente tumoral em pacientes portadores de neoplasias pulmonares e sua co-relacao com a presenca de macrofagos e celulas dendriticas.
• Beneficiário: Renato Brito Baleeiro
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 04/09956-0 - Modulação funcional de células dentríticas em diferentes situações fisiopatológicas
• Beneficiário: Jose Alexandre Marzagão Barbuto
• Modalidade de apoio: Auxílio à Pesquisa - Temático