Role of serotonin receptors in panic-like behavior induced by nitric oxide in the rat dorsolateral periaqueductal gray: effects of chronic clomipramine treatment

Autor(es)

Moreira, Fabrício de Araújo ^[1] ; Guimarães, Francisco Silveira

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Life Sciences; v. 77, n. 16, p. 1972-1982, 2005.
• Área do conhecimento: Ciências Biológicas - Farmacologia
• Assunto(s): Óxido nítrico Serotonina Clomipramina Transtorno de pânico Substância cinzenta periaquedutal

Resumo

Local administration of serotonin (5-HT) receptor agonists inhibits panic-like reactions induced by electrical stimulation of the rat dorsolateral periaqueductal grey (dlPAG). This anti-aversive effect is enhanced by chronic treatment with anti-panic drugs such as clomipramine. Since nitric oxide (NO) may mediate panic-like behavior in the dlPAG, we tested the hypothesis that chronic clomipramine treatment would also potentiate the effects of locally injected 5-HT-receptor agonists on panic-like reactions induced by intra-dlPAG injection of an NO-donor (SIN). After 21 days of daily i.p. injections of saline or clomipramine (10 mg/kg) male Wistar rats received local injections of saline, the 5-HT1A-receptor agonist 8-OH-DPAT (8 nmol) or the 5-HT2A/2C-receptor agonist DOI (16 nmol) followed by saline or SIN (150 nmol). NO-induced panic-like reactions were inhibited by DOI, but not by 8-OH-DPAT. Chronic clomipramine did not modify these effects but tended to produce anti-aversive effect by itself. In chronically clomipramine treated animals 8-OH-DPAT potentiated NO-induced panic-like reactions. The results indicate that the panic-like effects of NO in the dlPAG may be attenuated by 5-HT2A/2C-, but not by 5-HT1A-receptors. The anti-aversive effect of DOI is not modified by chronic clomipramine treatment. (AU)

• Processo FAPESP: 02/05406-0 - Efeitos do tratamento cronico com clomipramina na mediacao de respostas aversivas pelo oxido nitrico.
• Beneficiário: Fabricio de Araujo Moreira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 02/13197-2 - Participação do glutamato e óxido nítrico na fisiopatogenia de distúrbios neuropsiquiátricos
• Beneficiário: Francisco Silveira Guimaraes
• Modalidade de apoio: Auxílio à Pesquisa - Temático