Reciprocal interactions of obstructive sleep apnea and hypertension associated with ACE I/D polymorphism in males

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Koyama‚ R.G. ; Drager‚ L.F. ; Lorenzi-Filho‚ G. ; Cintra‚ F.D. ; Pereira‚ A.C. ; Poyares‚ D. ; Krieger‚ J.E. ; Castro‚ R.M. ; Tufik‚ S. ; De Mello‚ M.T. ; others

• Tipo de documento: Artigo Científico
• Fonte: Sleep Medicine; v. 10, n. 10, p. 1107-1111, 2009.

Resumo

Background: The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism gene contributes to the genesis of hypertension (HTN) and may help explain the relationship between obstructive sleep apnea (OSA) and HTN. However, ACE is a pleiotropic gene that has several influences, including skeletal muscle and control of ventilation. We therefore tested the hypothesis that ACE polymorphism influences OSA severity. Methods: Male OSA patients (apnea-hypopnea index [AHI] > 5 events/h) from 2 university sleep centers were evaluated by polysomnography and ACE I/D polymorphism genotyping. Results: We studied 266 males with OSA (age = 48 +/- 13y, body mass index = 29 5kg/m(2), AHI = 34 +/- 25events/h). HTN was present in 114 patients (43%) who were older (p < 0.01), heavier (p < 0.05) and had more severe OSA (p < 0.01). The I allele was associated with HTN in patients with mild to moderate OSA (p < 0.01), but not in those with severe OSA. ACE I/D polymorphism was not associated with apnea severity among normotensive patients. In contrast. the only variables independently associated with OSA severity among patients with hypertension in multivariate analysis were BMI (OR = 1.12) and 11 genotype (OR = 0.27). Conclusions: Our results indicate reciprocal interactions between OSA and HTN with ACE I/D polymorphism, suggesting that among hypertensive OSA males, the homozygous ACE I allele protects from severe OSA. (C) 2009 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 05/57504-4 - Busca da associacao dos alelos do gene da enzima conversora de angio tensina(eca) em pacientes com a sindrome de apneia obstrutiva do sono.
• Beneficiário: Renata Guedes Koyama
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs